Akter Tanzina, Zahan Md Sarwar, Nawal Nafisa, Rahman Md Hasanur, Tanjum Tayyabatun Nur, Arafat Kazi Ifthi, Moni Akhi, Islam Mohammad Nazrul, Uddin Md Jamal
ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh.
Department of Biotechnology, Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka-1207, Bangladesh.
Heliyon. 2023 Jun 2;9(6):e16957. doi: 10.1016/j.heliyon.2023.e16957. eCollection 2023 Jun.
Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women (4%-20%) when the ovaries create abnormally high levels of androgens, the male sex hormones that are typically present in women in trace amounts. The primary characteristics of PCOS include oxidative stress, inflammation, hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance. Generally, metformin, spironolactone, eflornithine and oral contraceptives are used to treat PCOS, despite their several side effects. Therefore, finding a potential candidate for treating PCOS is necessary. Curcumin is a major active natural polyphenolic compound derived from turmeric (). A substantial number of studies have shown that curcumin has anti-inflammatory, anti-oxidative stress, antibacterial, and anti-apoptotic activities. In addition, curcumin reduces hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance in various conditions, including PCOS. The review highlighted the therapeutic aspects of curcumin against the pathophysiology of PCOS. We also offer a hypothesis to improve the development of medicines based on curcumin against PCOS.
多囊卵巢综合征（PCOS）是女性中常见的一种激素紊乱疾病（发病率为4%-20%），其特征是卵巢产生异常高水平的雄激素，这种男性性激素在女性体内通常含量极少。PCOS的主要特征包括氧化应激、炎症、高血糖、高血脂、高雄激素血症和胰岛素抵抗。一般来说，二甲双胍、螺内酯、依氟鸟氨酸和口服避孕药用于治疗PCOS，尽管它们有多种副作用。因此，寻找治疗PCOS的潜在候选药物很有必要。姜黄素是从姜黄中提取的一种主要的活性天然多酚化合物。大量研究表明，姜黄素具有抗炎、抗氧化应激、抗菌和抗凋亡活性。此外，姜黄素在包括PCOS在内的各种情况下均可降低高血糖、高血脂、高雄激素血症和胰岛素抵抗。本综述强调了姜黄素针对PCOS病理生理学的治疗作用。我们还提出了一个假设，以促进基于姜黄素的抗PCOS药物的开发。
