Jiang Haoran, Kittipibul Veraprapas, Mahfoud Felix, Böhm Michael, Sobotka Paul A, Esler Murray, Wang Jie, Fudim Marat
Duke University School of Medicine, Durham, NC, USA.
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Heart Fail Rev. 2025 Mar;30(2):293-314. doi: 10.1007/s10741-024-10463-1. Epub 2024 Nov 7.
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interruption of sympathetic nerves connecting the kidney and the sympathetic nervous system can reduce blood pressure. Here, we present a review on how renal denervation can help hypertension patients, specifically focusing on our novel understanding of renal nerve anatomy, denervation technique, and subsequent clinical trials, and how it may be used to treat other cardiovascular diseases like heart failure.
交感神经系统的激活被认为与高血压的发展有关。两种已确立的治疗高血压的方法是药物治疗和生活方式改变。随着对肾神经解剖学和生理学的深入了解，肾去神经术已被提议作为高血压的一种替代治疗方法。具体而言，已表明中断连接肾脏和交感神经系统的交感神经可降低血压。在此，我们对肾去神经术如何帮助高血压患者进行综述，特别关注我们对肾神经解剖学、去神经技术及后续临床试验的新认识，以及它如何用于治疗心力衰竭等其他心血管疾病。
