State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Sci Adv. 2024 Oct 18;10(42):eadp8719. doi: 10.1126/sciadv.adp8719.
Optical imaging is a powerful tool for early disease detection and effective treatment planning, but its accuracy is often compromised by the uptake of imaging materials by the mononuclear phagocyte system (MPS). Herein, we leverage multivalent host-guest interactions between cyanine dyes and β-cyclodextrin polymers to develop supramolecular probes with enhanced stability, optical, and transport profiles for accurate in vivo imaging. These multivalent interactions not only ensure the stability of the probes but also enhance fluorescence efficiency by minimizing nonradiative decay. Our self-assembly approach effectively modulates probe size and surface properties, enabling evasion of MPS clearance and promoting prolonged bloodstream circulation, thereby improving the signal-to-background ratio for imaging. The effectiveness of our design is demonstrated by substantial advancements in the early diagnosis of acute kidney injury and by providing high-contrast imaging and precise surgical navigation across various tumor models. Our strategy not only advances optical imaging materials toward clinical translation but also establishes a versatile platform applicable to multiple imaging modalities.
光学成像是一种用于早期疾病检测和有效治疗规划的强大工具，但由于单核吞噬细胞系统 (MPS) 对成像材料的摄取，其准确性常常受到影响。在此，我们利用花菁染料和β-环糊精聚合物之间的多价主体-客体相互作用，开发出具有增强稳定性、光学和传输特性的超分子探针，以实现准确的体内成像。这些多价相互作用不仅确保了探针的稳定性，而且通过最小化非辐射衰减来提高荧光效率。我们的自组装方法有效地调节了探针的大小和表面特性，使其能够逃避 MPS 的清除，并促进延长血液循环，从而提高成像的信噪比。我们的设计通过在急性肾损伤的早期诊断中取得实质性进展，以及在各种肿瘤模型中提供高对比度成像和精确的手术导航，证明了其有效性。我们的策略不仅推动了光学成像材料向临床转化，而且还建立了一个适用于多种成像模式的通用平台。
