School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK; Physical Therapy Department, Faculty of Medical Rehabilitation Sciences, Taibah University, Madinah, Saudi Arabia.
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Exp Gerontol. 2024 Nov;197:112612. doi: 10.1016/j.exger.2024.112612. Epub 2024 Oct 21.
To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status.
RESEARCH METHODS & PROCEDURES: A cross-sectional study included 53,170 participants aged 60 years and over from the UK biobank (25,324 men and 27,846 women). The primary outcomes were grip strength index and muscle mass index, the predictor variable was n-3 fatty acid intake and the covariates were age, ethnicity, Townsend deprivation index, physical activity, multimorbidity count, total energy intake, body fat percentage and the month of assessment. Multivariable linear regression analyses were performed across 5 models. Model 1 was unadjusted; model 2 adjusted for age, ethnicity, deprivation index and month of assessment; model 3 adjusted as in model 2 plus total energy intake; model 4 as in model 2 plus multimorbidity count; and model 5 as in model 4 plus body fat percentage.
In model 5, higher n-3 fatty acid intake was positively associated with the grip strength index in women. For each additional gram of n-3 fatty acid consumed per day, there was an increase of 0.03 kg/m (95% CI: 0.00 to 0.06 kg/m) in active women and 0.04 kg/m (95% CI: 0.00 to 0.07 kg/m) in inactive women. However, no significant associations were observed in men, whether active (p = 0.405) or inactive (p = 0.323). Additionally, no significant associations were found between n-3 fatty acid intake and muscle mass index in either active (p = 0.858) or inactive (p = 0.250) men, or in active (p = 0.909) or inactive (p = 0.187) women.
Although n-3 fatty acid intake was associated with grip strength index in older women, regardless of their activity status, the magnitude of this association was very small and unlikely to be clinically relevant. Additionally, n-3 fatty acid was not associated with muscle mass index.
探讨 n-3 脂肪酸摄入量与老年人握力和肌肉质量指数的关系。次要目的是探讨这些关联是否因身体活动状况而异。
这项横断面研究纳入了英国生物库的 53170 名 60 岁及以上的参与者（25324 名男性和 27846 名女性）。主要结局指标是握力指数和肌肉质量指数，预测变量是 n-3 脂肪酸摄入量，协变量是年龄、种族、汤森贫困指数、身体活动、多种合并症计数、总能量摄入、体脂百分比和评估月份。在 5 个模型中进行了多变量线性回归分析。模型 1 未调整；模型 2 调整了年龄、种族、贫困指数和评估月份；模型 3 调整了总能量摄入；模型 4 调整了多种合并症计数；模型 5 调整了体脂百分比。
在模型 5 中，较高的 n-3 脂肪酸摄入量与女性的握力指数呈正相关。与每天多摄入 1 克 n-3 脂肪酸相比，活跃女性的握力指数增加 0.03kg/m（95%CI：0.00 至 0.06kg/m），不活跃女性增加 0.04kg/m（95%CI：0.00 至 0.07kg/m）。然而，在男性中，无论是活跃（p=0.405）还是不活跃（p=0.323），都没有观察到显著的关联。此外，在活跃（p=0.858）或不活跃（p=0.250）的男性，或在活跃（p=0.909）或不活跃（p=0.187）的女性中，n-3 脂肪酸摄入量与肌肉质量指数之间均未发现显著关联。
尽管 n-3 脂肪酸摄入量与老年女性的握力指数有关，无论其活动状态如何，但这种关联的幅度非常小，不太可能具有临床意义。此外，n-3 脂肪酸与肌肉质量指数无关。
