Department of Population Health and Primary Care, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Institute of Health and Community, Plymouth University, Peninsula Allied Health Centre, Derriford Road, Plymouth PL6 8BH, UK.
Nutrients. 2017 Oct 30;9(11):1189. doi: 10.3390/nu9111189.
Although fragility fractures, osteoporosis, sarcopenia, and frailty are becoming more prevalent in our aging society the treatment options are limited and preventative strategies are needed. Despite magnesium being integral to bone and muscle physiology, the relationship between dietary magnesium and skeletal muscle and bone health has not been investigated concurrently to date. We analysed cross-sectional associations between dietary magnesium and skeletal muscle mass (as fat free mass-FFM), grip strength, and bone density (BMD) in 156,575 men and women aged 39-72 years from the UK Biobank cohort. FFM was measured with bioelectrical impedance and was expressed as the percentage of body weight (FFM%) or as divided by body mass index (FFM). Adjusted mean grip strength, FFM%, FFM, and BMD were calculated according to quintiles of dietary magnesium, while correcting for covariates. Significant inter-quintile differences across intakes of magnesium existed in men and women, respectively, of 1.1% and 2.4% for grip strength, 3.0% and 3.6% for FFM%, 5.1% and 5.5% for FFM, and 2.9% and 0.9% for BMD. These associations are as great or greater than annual measured losses of these musculoskeletal outcomes, indicating potential clinical significance. Our study suggests that dietary magnesium may play a role in musculoskeletal health and has relevance for population prevention strategies for sarcopenia, osteoporosis, and fractures.
尽管在老龄化社会中，脆性骨折、骨质疏松症、肌肉减少症和衰弱症越来越普遍，但治疗选择有限，需要预防策略。尽管镁是骨骼和肌肉生理学的重要组成部分，但迄今为止，饮食镁与骨骼肌肉和骨骼健康之间的关系尚未同时进行调查。我们分析了来自英国生物库队列的 156575 名 39-72 岁男性和女性中饮食镁与骨骼肌质量（作为无脂肪质量-FFM）、握力和骨密度（BMD）之间的横断面关联。FFM 通过生物电阻抗法测量，并表示为体重的百分比（FFM%）或除以体重指数（FFM）。根据饮食镁的五分位数计算调整后的平均握力、FFM%、FFM 和 BMD，同时校正协变量。在男性和女性中，分别存在镁摄入量五分位数之间的显著差异，握力分别为 1.1%和 2.4%，FFM%分别为 3.0%和 3.6%，FFM 分别为 5.1%和 5.5%，BMD 分别为 2.9%和 0.9%。这些关联与这些肌肉骨骼结局的年测量损失一样大或更大，表明具有潜在的临床意义。我们的研究表明，饮食镁可能在肌肉骨骼健康中发挥作用，并且与肌肉减少症、骨质疏松症和骨折的人群预防策略相关。
