Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Doctor of Dental Surgery, Islamic Azad University of Medical Sciences, Esfahan, Iran.
Virol J. 2024 Oct 18;21(1):258. doi: 10.1186/s12985-024-02510-y.
Dental infections, such as apical Periodontitis, periodontitis, and peri-implantitis (PI), are closely associated with specific bacterial species, including Streptococcus mutans (S. mutans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum), among others. Antibiotics are extensively utilized for prophylactic and therapeutic purposes in the treatment of dental infections and other dental-related issues. Unfortunately, the rapid emergence of antimicrobial resistance has accompanied the increased use of antibiotics in recent years. Specific bacterial pathogens have reached a critical stage of antibiotic resistance, characterized by the proliferation of pan-resistant strains and the scarcity of viable therapeutic alternatives. Therapeutic use of particular bacteriophage (phage) particles that target bacterial pathogens is one potential alternative to antibiotics that are now being seriously considered for treating bacterial illnesses. A kind of virus known as a phage is capable of infecting and eliminating bacteria. Because they can't infect cells in plants and animals, phages might be a harmless substitute for antibiotics. To control oral disorders including periodontitis and dental caries, several research have been conducted in this area to study and identify phages from human saliva and dental plaque. The capacity of these agents to disturb biofilms expands their effectiveness against dental plaque biofilms and oral pathogens in cases of periodontitis, PI, and apical periodontitis. This review summarizes the current antibacterial properties of phages used to treat a variety of dental infections, such as periodontitis, peri-implantitis, infected dentin, and apical periodontitis.
口腔感染，如根尖周炎、牙周炎和种植体周围炎（PI），与特定的细菌种类密切相关，包括变形链球菌（S. mutans）、牙龈卟啉单胞菌（P. gingivalis）和核梭杆菌（F. nucleatum）等。抗生素在治疗口腔感染和其他口腔相关问题方面被广泛用于预防和治疗目的。然而，近年来随着抗生素的大量使用，抗生素耐药性的迅速出现已成为一个严重的问题。特定的细菌病原体已经达到了抗生素耐药性的关键阶段，其特征是泛耐药株的增殖和可行治疗替代品的稀缺。针对细菌病原体的特定噬菌体（噬菌体）颗粒的治疗用途是抗生素的一种潜在替代品，目前正在认真考虑用于治疗细菌疾病。噬菌体是一种能够感染和消灭细菌的病毒。由于它们不能感染动植物细胞，噬菌体可能是一种无害的抗生素替代品。为了控制包括牙周炎和龋齿在内的口腔疾病，已经在该领域进行了多项研究，以研究和鉴定来自人唾液和牙菌斑的噬菌体。这些药物干扰生物膜的能力增强了它们在治疗牙周炎、PI 和根尖周炎时对牙菌斑生物膜和口腔病原体的有效性。本综述总结了目前用于治疗各种口腔感染（如牙周炎、种植体周围炎、感染牙本质和根尖周炎）的噬菌体的抗菌特性。
