Universidade Federal do Espírito Santo, Programa de Pós-graduação em Biotecnologia, Vitória, ES, Brazil.
Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brazil.
Cancer Epidemiol. 2024 Dec;93:102687. doi: 10.1016/j.canep.2024.102687. Epub 2024 Oct 18.
In Brazil, regional disparities in mortality rates are evident. This study analyzes the mortality trends of head and neck squamous cell carcinoma (HNSCC) from 1998 to 2017 in Espírito Santo.
Data on deaths were obtained from the Unified Health System's Department of Informatics (DATASUS), and population statistics were sourced from the Brazilian Institute of Geography and Statistics (IBGE). Annual percentage change (APC) calculations with a 95 % confidence interval were used for standardization from 1998 to 2017. The analysis considered age, geographical healthcare regions, and specific anatomical sites (C00-06; C09-10; C12-13; C32; C14). Mortality rates adjusted for age and sex were computed for spatial distribution, focusing on Espírito Santo municipalities in two periods (1998-2007 and 2008-2017).
From 1998-2017, males aged 40-59 showed a rise in age-standardized mortality rate from 48.96 to 58.24/100,000. Espírito Santo experienced an increasing mortality trend in males across the health regions, whilst in females the increase was observed only in the Central region. Oral cavity, oropharynx and larynx subsites showed a mortality increase in males with APC of 1.1 %, 4.7 % and 2.6 %, respectively, while females had a rise only in oral cavity cancer deaths. Spatial analysis revealed higher mortality rates in both sexes during 2008-2017 compared to 1998-2007.
Our data highlighted an escalating mortality trend from 1998 to 2017 among men aged 40-80 in oral cavity, oropharynx and larynx, whereas the female population experienced a rise limited to oral cavity cancer mortality. As the only study covering this period in Espírito Santo, it serves as a valuable tool for developing strategies for HNSCC management, considering the socio-economic advancements achieved in recent years.
在巴西，死亡率的地区差异很明显。本研究分析了 1998 年至 2017 年巴西圣埃斯皮里图州头颈部鳞状细胞癌（HNSCC）的死亡趋势。
死亡数据来自于统一卫生系统的信息部门（DATASUS），人口统计数据来自巴西地理和统计研究所（IBGE）。1998 年至 2017 年期间，使用 95%置信区间的年百分比变化（APC）计算进行标准化。分析考虑了年龄、地理医疗区域和特定解剖部位（C00-06；C09-10；C12-13；C32；C14）。计算了年龄和性别调整后的死亡率，以关注 Espírito Santo 市在两个时期（1998-2007 年和 2008-2017 年）的空间分布。
1998 年至 2017 年期间，40-59 岁的男性年龄标准化死亡率从 48.96 上升到 58.24/100,000。在男性中，整个健康区的死亡率呈上升趋势，而在女性中，这一趋势仅在中部地区观察到。口腔、口咽和喉亚部位的死亡率在男性中分别以 APC1.1%、4.7%和 2.6%上升，而女性仅在口腔癌死亡中上升。空间分析显示，在 2008-2017 年期间，两性的死亡率均高于 1998-2007 年。
我们的数据突出表明，1998 年至 2017 年间，40-80 岁男性的口腔、口咽和喉的死亡率呈上升趋势，而女性人口仅在口腔癌死亡率方面有所上升。作为唯一一项涵盖这一时期的 Espírito Santo 研究，它为 HNSCC 管理策略的制定提供了有价值的工具，考虑到近年来取得的社会经济进步。
