Johansen Jørgen, Grau Eriksen Jesper
a Department of Oncology , Odense University Hospital, Institute of Clinical Research, University of Southern Denmark , Denmark.
Acta Oncol. 2016;55 Suppl 1:13-8. doi: 10.3109/0284186X.2015.1114672. Epub 2016 Jan 13.
Squamous cell carcinoma of the head and neck (HNSCC) comprises a variety of malignant tumors. Due to the rarity of each individual malignant entity, knowledge of epidemiological changes and trends over time may be derived from data compiled in regional and national registries. This study analyzed the development in incidence rates and mortality in elderly HNSCC patients in Denmark between 1980 and 2012 with specific attention to compliance to radiotherapy, the main treatment modality of HNSCC in Denmark.
HNSCC consisting of more than 25 patients per year over the age of 70 years were analyzed. This included cancer of the oral cavity defined as ICD-codes C00.3-4, C02-04, C05.0, C06; oropharynx as C01, C05.1-9, C09-10; and larynx as C32 recorded in the NORDCAN database. Additional data from the DAHANCA database was added to assess differences in compliance to treatment between younger and older patient groups.
HNSCC was predominant in younger patients. Only 17% were older than 70 years. The median age was 60 years. Generally, incidence rates rose for cancer of the oral cavity and oropharynx between 1980 and 2012 and stabilized for laryngeal cancer. Mortality rates had a shallower increase, especially in younger age groups, which translated into improved age-specific survival rates. Compliance to radiotherapy was high for all age groups. Failure to receive at least 60 Gy during radical radiation treatment was 2.3% despite a significant increase in patients with poor WHO performance status over time.
HNSCC is a rare disease in patients above 70 years accounting for only 17% of all HNSCC patients. Incidence rates increased over time, but age-specific survival rates improved, especially in younger patients. Failure rates to comply with radiation treatment, however, were low in both young and elderly patients.
头颈部鳞状细胞癌（HNSCC）包含多种恶性肿瘤。由于每种个体恶性肿瘤的罕见性，关于流行病学随时间变化和趋势的知识可能来自区域和国家登记处汇编的数据。本研究分析了1980年至2012年丹麦老年HNSCC患者的发病率和死亡率变化，特别关注丹麦HNSCC的主要治疗方式——放疗的依从性。
对每年超过25例70岁以上患者的HNSCC进行分析。这包括国际疾病分类（ICD）编码为C00.3 - 4、C02 - 04、C05.0、C06的口腔癌；C01、C05.1 - 9、C09 - 10的口咽癌；以及在NORDCAN数据库中记录为C32的喉癌。添加了来自DAHANCA数据库的其他数据，以评估年轻和老年患者组在治疗依从性方面的差异。
HNSCC在年轻患者中占主导。只有17%的患者年龄超过70岁。中位年龄为60岁。一般来说，1980年至2012年间口腔癌和口咽癌的发病率上升，喉癌发病率稳定。死亡率上升幅度较小，尤其是在年轻年龄组，这转化为特定年龄生存率的提高。所有年龄组的放疗依从性都很高。尽管随着时间推移世界卫生组织（WHO）体能状态差的患者显著增加，但根治性放疗期间未接受至少60 Gy的比例为2.3%。
HNSCC在70岁以上患者中是一种罕见疾病，仅占所有HNSCC患者的17%。发病率随时间增加，但特定年龄生存率提高，尤其是在年轻患者中。然而，年轻和老年患者的放疗不依从率都很低。
