Department of Nephrology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China.
Schoolof Pharmacy, Hunan Universityof Chinese Medicine, Changsha 410208, People's Republic of China.
Fitoterapia. 2024 Dec;179:106251. doi: 10.1016/j.fitote.2024.106251. Epub 2024 Oct 18.
Two new paraherquamides (PHQs) namely aculeaquamides B and C (1 and 2), along with four known PHQs (3-6), were isolated from the co-culture of marine fungus Aspergillus aculeatinus WHUF0198 and mangrove-associated fungus Penicillium sp. DM27. Compound 1 represents the first PHQ derivative featuring an uncommon 7/6/5/5/6/5 hexacyclic system. The structures of the isolated compounds were elucidated based on exhaustive NMR spectroscopy measurement and HRESIMS data. The absolute configurations of new compounds were determined by TDDFT-ECD calculations. Compound 3 demonstrated suppression of AngII-induced cardiac hypertrophy while exhibiting relatively low cardiomyocyte toxicity.
从海洋真菌棘孢曲霉 WHUF0198 和红树林相关真菌 Penicillium sp. DM27 的共培养物中分离得到两种新的拟海鞘素（PHQs），即刺鳞酰胺 B 和 C（1 和 2），以及四种已知的 PHQs（3-6）。化合物 1 代表了第一个具有不常见的 7/6/5/5/6/5 六环系统的 PHQ 衍生物。根据全面的 NMR 光谱测量和 HRESIMS 数据，确定了分离化合物的结构。新化合物的绝对构型通过 TDDFT-ECD 计算确定。化合物 3 表现出对 AngII 诱导的心肌肥大的抑制作用，同时显示出相对较低的心肌细胞毒性。
