Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, 530200, PR China.
J Antibiot (Tokyo). 2022 Sep;75(9):526-529. doi: 10.1038/s41429-022-00548-0. Epub 2022 Aug 2.
One new xanthene derivative, named penicixanthene E (1), together with one known compound 2, was isolated from the EtOAc extract of the endophytic fungus Penicillium sp. GXIMD 03101, which was identified from the mangrove Acanthus ilicifolius L. collected in the South China Sea. The structure of 1 was elucidated by 1D and 2D NMR spectral interpretation and HREISMS data. The absolute configurations of C-9 and C-11 in 1 were proposed based on electronic circular dichroism (ECD), but the configuration at C-3 in 1 was unassigned. Compound 1 represents a xanthene derivative that was first reported, in which carbon-carbon double bond has been reduced. The cytotoxic activities of all compounds were evaluated, the result showed that compound 1 has weak activity against pancreatic cancer SW1990.
从南海采集的红树林植物老鼠簕中分离到的内生真菌青霉 GXIMD 03101 的 EtOAc 提取物中分离得到一种新的氧杂蒽衍生物，命名为 penicixanthene E（1），以及一种已知化合物 2。通过 1D 和 2D NMR 谱解析和 HREISMS 数据确定了 1 的结构。根据电子圆二色性（ECD）确定了 1 中 C-9 和 C-11 的绝对构型，但 1 中 C-3 的构型未确定。化合物 1 代表了首次报道的氧杂蒽衍生物，其中碳-碳双键已被还原。对所有化合物的细胞毒性活性进行了评价，结果表明化合物 1 对胰腺癌 SW1990 具有较弱的活性。
