Caplin J L, Dymond D S, O'Keefe J C, Flatman W D, Dyke L, Banim S O, Spurrell R A
Br Heart J. 1986 Feb;55(2):120-8. doi: 10.1136/hrt.55.2.120.
Serial changes in left ventricular function on exercise were assessed by first pass radionuclide angiography with gold-195m (half life 30.5 s) in 25 men with known coronary anatomy. In the seven patients with three vessel disease, abnormalities of global left ventricular function and regional wall motion occurred earlier during exercise, were of greater extent at peak exercise, and persisted longer after exercise than in the 11 patients with one and two vessel disease or the seven with normal coronary arteries. Although there were significant differences between the groups in absolute change in ejection fraction and the rate of change in ejection fraction related to exercise duration and heart rate, a considerable overlap of values between groups precluded the accurate prediction of coronary anatomy in individuals. These data suggest that the amount of myocardium at risk from ischaemia in some patients with one and two vessel disease may resemble that in patients with three vessel disease. This study shows that an anatomical classification based solely on the number of diseased vessels will not predict the extent of the impairment of left ventricular function on exercise.
通过使用半衰期为30.5秒的195m金进行首次通过放射性核素血管造影，评估了25名已知冠状动脉解剖结构的男性在运动时左心室功能的系列变化。在7例三支血管病变患者中，与11例单支和双支血管病变患者或7例冠状动脉正常的患者相比，左心室整体功能和节段性室壁运动异常在运动早期出现，在运动峰值时程度更严重，且运动后持续时间更长。尽管各组之间在射血分数的绝对变化以及与运动持续时间和心率相关的射血分数变化率方面存在显著差异，但组间数值有相当大的重叠，无法准确预测个体的冠状动脉解剖结构。这些数据表明，一些单支和双支血管病变患者中面临缺血风险的心肌量可能与三支血管病变患者相似。这项研究表明，仅基于病变血管数量的解剖学分类无法预测运动时左心室功能受损的程度。
