Elliott A T, Dymond D S, Stone D L, Flatman W, Bett R, Cuninghame J G, Sims H E, Willis H H
Phys Med Biol. 1983 Feb;28(2):139-47. doi: 10.1088/0031-9155/28/2/003.
The development of a mercury-195m/gold-195m radionuclide generator system is described, together with the results of preliminary experiments in animals and in man. The daughter radionuclide has a half-life of 30.5 s with a principal gamma emission at 262 keV, ideal for use with the multicrystal camera but suitable also in conjunction with the Anger design. The half-life of the parent radionuclide is 40 h. The eluant in current use is 2.5 mM sodium cyanide, the column being stored under 2% sodium nitrate solution when not in use to prevent radiation damage. Generators capable of delivering 550 MBq of 195Aum in a 0.4 ml bolus have been used for first-pass nuclear angiocardiography, the half-life being long enough to permit administration via peripheral intravenous injection. The radiation dose associated with this radionuclide is much lower than that from conventional 99Tcm-labelled radiopharmaceuticals, permitting multiple sequential studies, even on children.
本文描述了汞 - 195m/金 - 195m放射性核素发生器系统的研制情况，以及在动物和人体上进行的初步实验结果。子放射性核素的半衰期为30.5秒，主要γ发射峰在262keV，非常适合与多晶体相机配合使用，也适用于安格设计。母放射性核素的半衰期为40小时。目前使用的洗脱剂是2.5mM氰化钠，柱子在不使用时储存在2%的硝酸钠溶液下以防止辐射损伤。能够在0.4ml推注中提供550MBq的195Au的发生器已用于首次通过核血管造影，其半衰期足够长，允许通过外周静脉注射给药。与这种放射性核素相关的辐射剂量远低于传统的99Tcm标记放射性药物，甚至可以对儿童进行多次连续研究。
