Lethuillier Valentine, Peyronnet Benoit, Richard Claire, Bensalah Charles-Karim, Mathieu Romain, Robin François, Faix Antoine, Roux Jean-Luc, Freton Lucas
Département d'urologie, CHU de Rennes, Rennes, France.
Département de rhumatologie, CHU de Rennes, Rennes, France.
Fr J Urol. 2024 Nov;34(14):102759. doi: 10.1016/j.fjurol.2024.102759. Epub 2024 Oct 18.
Peyronie's and Dupuytren's diseases are benign but are source of significant functional impairment leading to considerable suffering. In this study, the aim is to investigate the association between Peyronie's and Dupuytren's diseases as well as their common and specific risk factors.
From July 2022 to March 2024, we conducted a multicentric observational study on 450 patients. Patients followed up for Peyronie's and/or Dupuytren's disease were given a questionnaire that included a consent form, in order to screen one or the other associated disease and explore all risk factors.
Among the 278 patients followed for Dupuytren's disease, 35 (12.3%) had Peyronie's disease. Of the 172 patients with initial Peyronie's disease, 50 (29.1%) were diagnosed with Dupuytren's disease. Eventually, 85 patients had both pathologies (18.9%). High blood pressure was significantly more prevalent in patients with both diseases, compared to subjects with Peyronie's disease only (37.7% vs. 38.4% vs. 24.4%; P=0.02). The same observation was made regarding smoking (62.3% vs. 60.7% vs. 48.8%; P=0.05) and daily alcohol consumption (52.9% vs. 41.7% vs. 35.8%; P=0.04). Patients diagnosed with isolated Dupuytren's disease were more likely to be diabetic (13.6% vs. 9.41%; P=0.42). Blue eyes and family history were significantly more often reported in Dupuytren's patients (33.9% vs. 22.8%; P=0.03; P<0.001). Ledderhose disease was significantly more prevalent in patients with both diseases or isolated Dupuytren's disease (21.2% vs. 12.4% vs. 3.3%; P=0.0003).
This study confirms the association between Peyronie and Dupuytren diseases. Smoking, alcohol daily consumption and hypertension are more prevalent in case of associated diseases. Blue eyes and family history are significantly more frequently found in case of Dupuytren's contracture. More powerful studies including a control group are necessary.
佩罗尼氏病和迪皮特朗挛缩症均为良性疾病，但会导致严重的功能障碍，给患者带来巨大痛苦。本研究旨在调查佩罗尼氏病和迪皮特朗挛缩症之间的关联以及它们的共同和特定风险因素。
2022年7月至2024年3月，我们对450名患者进行了一项多中心观察性研究。对因佩罗尼氏病和/或迪皮特朗挛缩症接受随访的患者发放了一份包含同意书的问卷，以筛查一种或另一种相关疾病并探究所有风险因素。
在278名因迪皮特朗挛缩症接受随访的患者中，35名（12.3%）患有佩罗尼氏病。在172名最初患有佩罗尼氏病的患者中，50名（29.1%）被诊断出患有迪皮特朗挛缩症。最终，85名患者同时患有这两种疾病（18.9%）。与仅患有佩罗尼氏病的患者相比，同时患有这两种疾病的患者中高血压更为普遍（37.7%对38.4%对24.4%；P = 0.02）。吸烟（62.3%对60.7%对48.8%；P = 0.05）和每日饮酒（52.9%对41.7%对35.8%；P = 0.04）情况也有相同发现。被诊断为孤立性迪皮特朗挛缩症的患者患糖尿病的可能性更大（13.6%对9.41%；P = 0.42）。迪皮特朗挛缩症患者中蓝眼睛和家族史的报告更为频繁（33.9%对22.8%；P = 0.03；P < 0.001）。莱德霍斯病在同时患有这两种疾病或孤立性迪皮特朗挛缩症的患者中更为普遍（21.2%对12.4%对3.3%；P = 0.0003）。
本研究证实了佩罗尼氏病和迪皮特朗挛缩症之间的关联。在相关疾病患者中，吸烟、每日饮酒和高血压更为普遍。在迪皮特朗挛缩症患者中，蓝眼睛和家族史更为常见。需要开展包括对照组在内的更有力的研究。
