Nyberg L M, Bias W B, Hochberg M C, Walsh P C
J Urol. 1982 Jul;128(1):48-51. doi: 10.1016/s0022-5347(17)52751-2.
Peyronie's disease is an inflammatory disorder with no confirmed etiology. We have documented the familial transmission of the disease as an autosomal dominant trait in 3 pedigrees. The occurrence of Dupuytren's contracture in 7 of 9 (78 per cent) affected individuals, which is a significant increase over the average 0 per cent reported in sporadic cases, suggests that both of these fibrosing disorders are pleiotropic effects of the same gene in these families. Similarly, the histocompatibility B7 cross-reacting antigens were present in 90 per cent of the patients with Peyronie's disease. Additional studies, including careful family histories and histocompatibility antigen typing, are necessary to elucidate the role of histocompatibility antigens as a relative risk factor.
佩罗尼氏病是一种病因未明的炎症性疾病。我们已在3个家系中记录了该病作为常染色体显性性状的家族性传播。9名受影响个体中有7名（78%）出现了掌腱膜挛缩，这比散发病例报告的平均0%有显著增加，表明在这些家族中，这两种纤维化疾病是同一基因的多效性效应。同样，90%的佩罗尼氏病患者存在组织相容性B7交叉反应抗原。需要进行更多研究，包括详细的家族史和组织相容性抗原分型，以阐明组织相容性抗原作为相对危险因素的作用。
