Doreen M S, Boardman P L, Fowler P D, Poole P H
Rheumatol Rehabil. 1979;Suppl 2:78-80.
A double-blind trial compared diclofenac with placebo in 44 outpatients. On from each group dropped out with dyspepsia, and one (placebo group) with ineffective treatment. Twenty completers received diclofenac. Dosage was one tablet (25 mg diclofenac) three times daily during the first week. In the second (final) week, most patients had four or six tablets. Diclofenac had significantly greater effect on pain, grip, morning stiffness, joint tenderness and swelling, and in comparison to previous treatments, even though the placebo group required significantly more rescue anaglesic. A few patients in each group had slight dyspepsia. One in the active and six in the placebo group complained of minor central nervous system symptoms. There were no serious side-effects. Haematological, biochemical and urinary analyses showed no clinically important changes. It is concluded that, in the short term, diclofenac (Voltarol) is effective in relieving the symptoms of inflammatory polyarthritis. It is well tolerated as placebo medication, and had no detrimental haematological or biochemical effects.
一项双盲试验对44名门诊患者使用双氯芬酸与安慰剂进行了比较。每组均有1名患者因消化不良退出，安慰剂组有1名患者因治疗无效退出。20名完成试验的患者接受了双氯芬酸治疗。第一周剂量为每日3次，每次1片（含双氯芬酸25毫克）。在第二周（最后一周），大多数患者服用4至6片。双氯芬酸对疼痛、握力、晨僵、关节压痛和肿胀的疗效显著优于安慰剂，与之前的治疗方法相比也是如此，尽管安慰剂组需要显著更多的急救镇痛药。每组有少数患者有轻微消化不良。治疗组有1名患者、安慰剂组有6名患者主诉有轻微中枢神经系统症状。无严重副作用。血液学、生化和尿液分析未显示出具有临床意义的变化。结论是，短期内，双氯芬酸（扶他林）可有效缓解炎症性多关节炎的症状。其耐受性与安慰剂相当，对血液学或生化指标无不良影响。
