Treadwell B L, Tweed J M
N Z Med J. 1979 Jan 24;89(628):43-5.
The clinical activity and side effects of a new phenyl acetic-acid derivative, diclofenac, have been assessed in 24 patients with rheumatoid disease. Diclofenac 25 mg q.i.d. was compared with 750mg of aspirin BP q.i.d. using a double-blind crossover technique involving four weeks on each drug. Benefits were similar for the two preparations but with improvement in morning stiffness and incidence of dyspepsia favouring diclofenac, and a more marked reduction of the sedimentation rate occurring with aspirin. A moderate elevation of liver enzymes was seen in one patient on diclofenac, and of lactate dehydrogenase in one other. It is concluded that diclofenac is a therapeutically active analgesic anti-inflammatory agent.
对24例类风湿病患者评估了一种新型苯乙酸衍生物双氯芬酸的临床活性及副作用。采用双盲交叉技术，让患者每种药物服用四周，将每日四次、每次25毫克的双氯芬酸与每日四次、每次750毫克的英国药典阿司匹林进行比较。两种制剂的疗效相似，但双氯芬酸在改善晨僵和消化不良发生率方面更具优势，而阿司匹林在降低血沉方面效果更显著。服用双氯芬酸的1例患者出现肝酶中度升高，另1例患者乳酸脱氢酶升高。结论是双氯芬酸是一种具有治疗活性的镇痛抗炎药。
