Cardoe N, Fowler P D
Rheumatol Rehabil. 1979;Suppl 2:89-99.
A double-blind comparative trial in 60 patients, using diclofenac (Voltarol) and ibuprofen (Brufen), showed a considerable improvement in morning stiffness amongst females in the diclofenac group. However, no significant differences was noted between these two drugs in relation to pain score, articular index or proximal interphalangeal joint size. Analysis of withdrawals and side-effects suggests that while ibuprofen may be slightly better tolerated, it is also associated with significantly more withdrawals due to lack of effect. No significant change in laboratory studies was noted, except for a slight decrease in mean haemoglobin levels. The trialist noted that all of the drop-outs and side-effects reported came from one hospital out of the four participating; this was possibly due to differences in pre-trial drug therapy and to the hospital being in an urban, rather a rural, situation.
一项针对60名患者的双盲对比试验，使用双氯芬酸（扶他林）和布洛芬（布洛芬），结果显示双氯芬酸组女性的晨僵有显著改善。然而，在疼痛评分、关节指数或近端指间关节大小方面，这两种药物之间没有显著差异。对停药情况和副作用的分析表明，虽然布洛芬的耐受性可能稍好一些，但因疗效不佳导致的停药情况也明显更多。除了平均血红蛋白水平略有下降外，实验室研究未发现显著变化。试验者指出，所有报告的退出试验情况和副作用都来自四个参与医院中的一家；这可能是由于试验前药物治疗的差异以及该医院位于城市而非农村地区。
