Arushanian E B, Popova A P
Biull Eksp Biol Med. 1986 Jan;101(1):89-91.
Haloperidol-induced (0.25-1.0 mg/kg) catalepsy in rats is characterized by rhythmic time fluctuations. Marked catalepsy was accompanied by slow regular waves at 2-4 and 5-7 min period. Natural or L-dopa-induced inhibition of the process involves the phase of irregular and frequent fluctuations. The study of time fluctuations of the muscular tone are believed important for predicting the development of drug-induced Parkinson's disease.
氟哌啶醇诱导（0.25 - 1.0毫克/千克）的大鼠僵住症具有节律性的时间波动特征。明显的僵住症在2 - 4分钟和5 - 7分钟周期时伴有缓慢的规则波。自然或左旋多巴诱导的该过程抑制涉及不规则且频繁波动的阶段。肌肉张力的时间波动研究被认为对预测药物诱导的帕金森病的发展很重要。
