Arushanian E B, Binatova N Iu, Popov A V, Popova A P
Farmakol Toksikol. 1991 Jul-Aug;54(4):8-11.
The acute administration of the pineal hormone melatonin (1 mg/kg) to rats was shown to increase, and the chronic use to decrease intensity of haloperidol-induced catalepsy with the reorganization of the rhythmic pattern of the neuroleptic effect. The direct opposite shifts were observed after pinealectomy or propranolol chronic administration (1 mg/kg). It is suggested that owing to its own adaptive properties the pineal gland can participate in the formation of drug tolerance.
给大鼠急性注射松果体激素褪黑素（1毫克/千克）可增强氟哌啶醇诱导的僵住症的强度，而长期使用则会降低其强度，并使抗精神病作用的节律模式发生重组。松果体切除或长期注射普萘洛尔（1毫克/千克）后，观察到的变化则完全相反。这表明，由于自身的适应性特性，松果体可能参与了药物耐受性的形成。
