Rathore Seema S, Leno Jenita J Josephine, Dotherabandi Manjula
Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore, India.
J Biomater Sci Polym Ed. 2025 Apr;36(5):605-646. doi: 10.1080/09205063.2024.2416293. Epub 2024 Oct 21.
Hyaluronic acid, a non-sulphated glycosaminoglycan has attracted its usage in the management of breast cancer. Drug-loaded nanoparticles with hyaluronic acid surface modifications show potential as a promising method for targeting and delivering drugs to the tumor site. The aim of this study was to conduct a systematic review of articles and assess the impact of hyaluronic acid coated nanoparticles on breast cancer. The various database were used for this comprehensive review. The inclusion and exclusion criteria were selected according to the PRISMA guidelines. Studies associated with characterization, , and studies were collected and subjected for further analysis. According to the inclusion criteria, 41 literature were selected for analysis. From all the studies, it was observed that the nanoparticles coated with hyaluronic acid produced better particle size, shape, zeta potential, increased cytotoxicity, cellular uptake, cell apoptosis, and anti-tumor effect . Research has shown that hyaluronic acid exhibits a higher affinity for CD44 receptors, resulting in enhanced targeted nanoparticle activity on cancer cells while sparing normal cells.
透明质酸是一种非硫酸化糖胺聚糖，已在乳腺癌治疗中得到应用。表面修饰有透明质酸的载药纳米颗粒显示出作为一种有前景的方法用于将药物靶向递送至肿瘤部位的潜力。本研究的目的是对文章进行系统综述，并评估透明质酸包被的纳米颗粒对乳腺癌的影响。为此综合综述使用了各种数据库。根据PRISMA指南选择纳入和排除标准。收集了与表征相关的研究以及其他研究并进行进一步分析。根据纳入标准，选择了41篇文献进行分析。从所有研究中观察到，包被有透明质酸的纳米颗粒产生了更好的粒径、形状、zeta电位，增强了细胞毒性、细胞摄取、细胞凋亡和抗肿瘤作用。研究表明，透明质酸对CD44受体表现出更高的亲和力，从而增强了纳米颗粒对癌细胞的靶向活性，同时使正常细胞免受影响。
