Meeker W R, Sickle-Santanello B J, Philpott G, Kenady D, Bland K I, Hill G H, Popp M B
Cancer. 1986 Feb 1;57(3):525-9. doi: 10.1002/1097-0142(19860201)57:3<525::aid-cncr2820570320>3.0.co;2-v.
Combined chemotherapy and radiation therapy have been reported to produce a high incidence of complete regression of epithelial cancer of the anal canal, resulting in prolonged disease-free survival. This modality has been advocated as an alternative to abdominoperineal resection as a primary treatment for this disease. Our group treated 19 patients between 1979 and 1985. Treatment included two infusions of 5-fluorouracil (1000 mg/m2/24 hours), one dose of mitomycin C (15 mg/m2), and simultaneous whole-pelvis radiation (3000 rad). The complete response rate was 88%. Three patients had anal cancer incompletely controlled by that therapy. They underwent abdominoperineal resections and are alive without disease at 10, 39, and 43 months, respectively. Actuarial disease-free survival at 40 months was 87.5 +/- 8.8 (% +/- standard error of the mean [SEM]). Complications included gastrointestinal, hematologic, and cutaneous toxicity. These results confirmed a high complete response rate to this therapy. Local treatment failures may occur, but these may be salvaged with abdominoperineal resection.
据报道，联合化疗和放疗可使肛管上皮癌的完全缓解率很高，从而延长无病生存期。这种治疗方式已被提倡作为腹会阴联合切除术的替代方案，作为该病的主要治疗方法。我们的研究小组在1979年至1985年间治疗了19名患者。治疗包括两次输注5-氟尿嘧啶（1000mg/m²/24小时）、一剂丝裂霉素C（15mg/m²）以及同时进行全盆腔放疗（3000拉德）。完全缓解率为88%。有3例患者的肛管癌未被该治疗完全控制。他们接受了腹会阴联合切除术，分别在10个月、39个月和43个月时无病存活。40个月时的精算无病生存率为87.5±8.8（%±平均标准误差[SEM]）。并发症包括胃肠道、血液学和皮肤毒性。这些结果证实了该治疗具有较高的完全缓解率。可能会出现局部治疗失败，但可通过腹会阴联合切除术挽救。
