Huang Huifang, Wu Kunhai, Deng Gaoxiang, Zhang Yuqin
Intensive Care Unit, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Blood Transfusion Department, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Int J Gen Med. 2024 Oct 15;17:4617-4626. doi: 10.2147/IJGM.S483696. eCollection 2024.
Blood transfusions are performed in small amounts in premature infants. Few studies have focused on the effect of the same red blood cell (RBC) package at different intervals on increasing hemoglobin(Hb) concentration. We aimed to determine the effect of infusion of the same RBC package at different time intervals on Hb levels in premature infants.
Data were collected about premature infants who received the same package of RBC transfusion at two different intervals. Venous blood Hb levels before and within 24 hours after transfusion were measured for the first and second transfusions. Overall, 196 premature infants with anemia were included in the study. The data were categorized into four groups (Group I, Group II, Group III and Group IV) based on the varying intervals between transfusions of the same red blood cells.
Hb levels of the first and second transfusions with the same RBC package showed a significant difference pre and posttransfusion. Hb increments varied among groups: Group I (43.00 g/L), Group II (34.50 g/L), Group III (32.00 g/L), and Group IV (32.50 g/L), with Group I demonstrating a significant difference compared to Groups II, III, and IV (P<0.05), while no differences were noted among the latter groups.
In premature infants with anemia, hemoglobin levels significantly increased after infusion of the same RBC package at different intervals. An interval of 1 week had the most significant effect.
There are differences in the effect of infusion of the same RBC at different time intervals on hemoglobin levels in premature infants. An interval of 1 week had the most significant effect.
对早产儿进行少量输血。很少有研究关注同一红细胞（RBC）包在不同时间间隔输注对血红蛋白（Hb）浓度升高的影响。我们旨在确定同一RBC包在不同时间间隔输注对早产儿Hb水平的影响。
收集在两个不同时间间隔接受同一包RBC输血的早产儿的数据。在首次和第二次输血前及输血后24小时内测量静脉血Hb水平。总体而言，196例贫血早产儿纳入本研究。根据同一红细胞输血间隔的不同，将数据分为四组（I组、II组、III组和IV组）。
同一RBC包首次和第二次输血的Hb水平在输血前后有显著差异。各组Hb升高幅度不同：I组（43.00 g/L）、II组（34.50 g/L）、III组（32.00 g/L）和IV组（32.50 g/L），I组与II组、III组和IV组相比有显著差异（P<0.05），而后三组之间无差异。
在贫血早产儿中，同一RBC包在不同时间间隔输注后血红蛋白水平显著升高。间隔1周的效果最为显著。
同一RBC在不同时间间隔输注对早产儿血红蛋白水平的影响存在差异。间隔1周的效果最为显著。
