Schwartz S E, Fazio T L
Scand J Gastroenterol. 1979;14(6):747-51. doi: 10.3109/00365527909181948.
The effects of an intramuscular injection of atropine (0.6 mg) and meperidine (1 mg/kg body weight) 30 min before topical benzocaine and intravenous diazepam administration were compared with those of a control group that received only benzocaine and intravenous diazepam in a randomized double-blind controlled trial of premedication for upper gastrointestinal endoscopy in 100 consecutive patients. Atropine and meperidine decreased the amount of salivation and gastric secretion (p less than 0.001 and p less than 0.001, respectively) and increased the period of sedation (p less than 0.001). The patients' and examiners' evaluation of the procedure was the same with either premedication regimen. Neither regimen affected the success rate of the endoscopy. Regardless of the regimen used, every patient who underwent endoscopy stated that they would consent to another examination, if necessary. Patients judged before endoscopy to be most apprehensive tolerated the procedure least, and those judged to be least apprehensive tolerated the procedure best, irrespective of premedication. The addition of meperidine and atropine to a premedication regimen of diazepam and topical benzocaine does not appear to be beneficial.
在一项针对100例连续患者进行的上消化道内镜检查术前用药的随机双盲对照试验中，比较了在局部应用苯佐卡因和静脉注射地西泮前30分钟肌肉注射阿托品（0.6毫克）和哌替啶（1毫克/千克体重）的效果与仅接受苯佐卡因和静脉注射地西泮的对照组的效果。阿托品和哌替啶减少了唾液分泌量和胃液分泌量（分别为p<0.001和p<0.001），并延长了镇静时间（p<0.001）。两种术前用药方案下患者和检查者对检查过程的评价相同。两种方案均未影响内镜检查的成功率。无论采用何种方案，每例接受内镜检查的患者均表示如有必要，他们会同意再次检查。在内镜检查前被判定最焦虑的患者对检查过程的耐受性最差，而被判定最不焦虑的患者对检查过程的耐受性最好，与术前用药无关。在苯二氮䓬类药物和局部应用苯佐卡因的术前用药方案中添加哌替啶和阿托品似乎并无益处。
