Bianchi Porro G, Baroni S, Parente F, Lazzaroni M
Gastrointestinal Unit, L. Sacco Hospital, Milan, Italy.
Gastrointest Endosc. 1988 May-Jun;34(3):252-4. doi: 10.1016/s0016-5107(88)71323-1.
The effectiveness of midazolam as premedication for upper gastrointestinal endoscopy was examined and compared with that of diazepam in a double-blind crossover study involving 23 patients. The degree of sedation and cooperation of patients during the procedure and the speed of recovery from sedation were comparable for the two drugs. The effects of both compounds on arterial blood pressure and heart rate were quite similar. However, midazolam induced significantly more amnesia than diazepam (91% vs. 39%). Also, patients' acceptability for the procedure was significantly higher in the midazolam than in the diazepam group (78% vs. 26%). Therefore, when amnesia is desirable, as in the case of repeated endoscopies, midazolam should be the drug of choice.
在一项涉及23名患者的双盲交叉研究中，对咪达唑仑作为上消化道内镜检查术前用药的有效性进行了检验，并与地西泮进行了比较。两种药物在操作过程中患者的镇静程度和配合度以及镇静恢复速度方面相当。两种化合物对动脉血压和心率的影响非常相似。然而，咪达唑仑诱导的遗忘作用明显强于地西泮（91%对39%）。此外，咪达唑仑组患者对该操作的接受度显著高于地西泮组（78%对26%）。因此，当需要遗忘作用时，如在重复内镜检查的情况下，咪达唑仑应作为首选药物。
