Zhang Yu-Nuo, Ouyang Wei-Jie, Hu Jiao-Yue, Liu Zu-Guo
Xiamen University Affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Fujian Engineering and Research Center of Eye Regenerative Medicine; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen 361005, Fujian Province, China.
Department of Ophthalmology, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China.
Int J Ophthalmol. 2024 Oct 18;17(10):1911-1920. doi: 10.18240/ijo.2024.10.19. eCollection 2024.
Dry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex. The oxidative stress reaction is considered to be among the important factors in the pathogenesis of dry eye. Therefore, activating the antioxidant system has a potential therapeutic effect on dry eye. Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is considered the most important antioxidant pathway in the body. The activation of the Nrf2 signaling pathway and its interaction with other pathways are important mechanisms to prevent the occurrence and development of dry eye. This review describes the structure and function of Nrf2, summarizes the changes in the oxidative stress response in dry eye, focuses on the potential mechanism of the Nrf2 signaling pathway in the treatment of dry eye, and, finally, summarizes the drugs that activate the Nrf2 signaling pathway in the treatment of dry eye.
干眼症是最常见的眼表疾病，可导致眼表组织损伤和不适症状，严重影响人们的生活质量。干眼症的病因多种多样，其发病机制复杂。氧化应激反应被认为是干眼症发病机制中的重要因素之一。因此，激活抗氧化系统对干眼症具有潜在的治疗作用。核因子红细胞2相关因子2（Nrf2）信号通路被认为是体内最重要的抗氧化途径。Nrf2信号通路的激活及其与其他途径的相互作用是预防干眼症发生和发展的重要机制。本文综述了Nrf2的结构和功能，总结了干眼症中氧化应激反应的变化，重点阐述了Nrf2信号通路在干眼症治疗中的潜在机制，最后总结了在干眼症治疗中激活Nrf2信号通路的药物。
