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通过对出土人类骨骼中观察到的贫血迹象追踪青铜时代(约公元前3200 - 2200年)舒尔赫塔(燃烧之城)的传染病情况。

Tracking of Infectious Diseases in Shahr-i Sokhta (Burnt City) during the Bronze Age (ca. 3200-2200 BCE) through Anemic Signs Observed in Excavated Human Skeletons.

作者信息

Bizhani Negar, Vincenti Giorgia, Sajjadi Seyyed Mansur Seyyed, Dupouy-Camet Jean, Shirazi Rouhollah, Nateghpour Mehdi, Kargar Faranak, Shariati Vahid, Fabbri Pier Francesco, Mowlavi Gholamreza

机构信息

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Public Health. 2024 Jun;53(6):1416-1426.

Abstract

BACKGROUND

The intriguing area of paleopathology merges the disciplines of archeology and biological studies. Using this line of research, it is possible to identify diseases that have left skeletal traces in the past. In addition, diseases such as various anemia that occur in childhood, when bone tissue is soft and retains evidence, can be identified in ancient bones. Cribra orbitalia (Co, cribra cranii (Cc, and porotic hyperostosis (Ph were ancient skeletal remains' most common degenerative anomalies.

METHODS

Shahr-i Sokhta dated back to 3200-1800 BCE, is the subject of our research; it is located in Sistan and Baluchistan province (Iran). The research was done on the archaeological data collected during the MAIPS expeditions at Shahr-i Sokhta (2017-2021) kept at the storage of the excavated materials on the site. The skeletal remains were examined for bone abnormalities such as Co, Cc, and Ph. These symptoms were analyzed to obtain traces of anemia-related diseases at this site. Data has been utilized following the Data Collection Codebook.

RESULTS

Ninety-six adults were studied while the anemic signs of CC and Co are respectively seen in 27/72 (37.5 %) and 10/57 (17; 5 %), and these samples have been kept for future analysis.

CONCLUSION

Bones may narrate a person's life, their gender and how old they were when they died besides the diseases they had. Some of the skeletons show signs of anemia, Classical paleopathology lets us to re-confirm studying diseases by further targeted sampling using molecular methods.

摘要

背景

古病理学这一引人入胜的领域融合了考古学和生物学研究学科。通过这一研究方向,有可能识别过去留下骨骼痕迹的疾病。此外,诸如各种在儿童时期发生的贫血症等疾病,当骨组织柔软且保留证据时,也能在古代骨骼中被识别出来。眶筛孔(Co)、颅骨筛孔(Cc)和多孔性骨质增生(Ph)是古代骨骼遗骸中最常见的退行性异常。

方法

沙赫里苏赫塔可追溯到公元前3200 - 1800年,是我们的研究对象;它位于锡斯坦 - 俾路支斯坦省(伊朗)。这项研究是基于在沙赫里苏赫塔(2017 - 2021年)的MAIPS探险期间收集的考古数据进行的,这些数据保存在该遗址出土材料的储存处。对骨骼遗骸检查是否存在如Co、Cc和Ph等骨骼异常情况。对这些症状进行分析以获取该遗址与贫血相关疾病的痕迹。数据是按照《数据收集手册》使用的。

结果

研究了96名成年人,而CC和Co的贫血迹象分别在27/72(37.5%)和10/57(17.5%)中被观察到,并且这些样本已被留存以供未来分析。

结论

骨骼除了能揭示一个人所患疾病外,还能讲述其生平、性别以及死亡时的年龄。一些骨骼显示出贫血迹象,经典古病理学让我们通过使用分子方法进行进一步的靶向采样来重新确认对疾病的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9120/11488546/e9db32ddfcd7/IJPH-53-1416-g001.jpg

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