Yosefzadeh Yosef, Rezaei Mahdokht, Allami Abbas, Hosseinsabet Ali
Department of Cardiology, Bouali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Cardiology, Faculty of Medicine, Bouali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
J Cardiovasc Thorac Res. 2024;16(3):164-170. doi: 10.34172/jcvtr.33184. Epub 2024 Sep 20.
Previous studies have investigated the potential influence of prior aspirin use on cardiac function in patients with ST-elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary intervention (PPCI). However, the results from these studies have been conflicting. This study aimed to investigate whether prior aspirin use affects left ventricular (LV) function in these patients using echocardiography.
The study included 260 consecutive STEMI patients, who were divided into two groups based on the presence or absence of prior aspirin use. Echocardiographic parameters, such as maximal left atrial (LA) size, LV ejection fraction (LVEF), early diastolic velocity (e'), E/A ratio, and E/e' ratio, were assessed within 72 hours of admission.
Aspirin users had an older age compared to non-users, as well as lower body mass index and renal function. They also had a greater history of hypertension and were more likely to be taking statins, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and calcium channel blockers. There were no significant differences in LVEF, maximal LA size, E/A ratio, E/e' ratio, and deceleration time between aspirin users and non-users. e' wave was marginally lower in aspirin users (=0.054). After controlling for confounding variables, the previous use of aspirin did not show a significant impact.
Prior aspirin use in STEMI patients does not have a significant impact on LV echocardiographic parameters. Our conclusions remained consistent even after adjusting for potential confounders.
既往研究探讨了既往使用阿司匹林对接受直接经皮冠状动脉介入治疗（PPCI）的ST段抬高型心肌梗死（STEMI）患者心脏功能的潜在影响。然而，这些研究结果相互矛盾。本研究旨在使用超声心动图研究既往使用阿司匹林是否会影响这些患者的左心室（LV）功能。
该研究纳入了260例连续的STEMI患者，根据是否既往使用阿司匹林将其分为两组。在入院72小时内评估超声心动图参数，如最大左心房（LA）大小、左心室射血分数（LVEF）、舒张早期速度（e'）、E/A比值和E/e'比值。
与未使用者相比，阿司匹林使用者年龄更大，体重指数和肾功能更低。他们患高血压的病史也更长，更有可能服用他汀类药物、血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂和钙通道阻滞剂。阿司匹林使用者和未使用者之间在LVEF、最大LA大小、E/A比值、E/e'比值和减速时间方面无显著差异。阿司匹林使用者的e'波略低（=0.054）。在控制混杂变量后，既往使用阿司匹林未显示出显著影响。
STEMI患者既往使用阿司匹林对LV超声心动图参数无显著影响。即使在调整潜在混杂因素后，我们的结论仍然一致。
