流感期间免疫控制的定量映射
Quantitatively Mapping Immune Control during Influenza.
作者信息
Weaver Jordan J A, Smith Amber M
机构信息
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163 USA.
出版信息
Curr Opin Syst Biol. 2024 Jun;38. doi: 10.1016/j.coisb.2024.100516. Epub 2024 Mar 20.
Abstract
Host immune responses play a pivotal role in defending against influenza viruses. The activation of various immune components, such as interferon, macrophages, and CD8+ T cells, works to limit viral spread while maintaining lung integrity. Recent mathematical modeling studies have investigated these responses, describing their regulation, efficacy, and movement within the lung. Here, we discuss these studies and their emphasis on identifying nonlinearities and multifaceted roles of different cell phenotypes that could be responsible for spatially heterogeneous infection patterns.
摘要
宿主免疫反应在抵御流感病毒中起关键作用。各种免疫成分的激活，如干扰素、巨噬细胞和CD8+ T细胞，在维持肺完整性的同时限制病毒传播。最近的数学建模研究对这些反应进行了调查，描述了它们在肺内的调节、功效和移动情况。在此，我们讨论这些研究及其对识别不同细胞表型的非线性和多方面作用的强调，这些作用可能导致空间异质性感染模式。
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