Saeki Yuma, Higashisaka Kazuma, Izutani Rina, Seo Jiwon, Miyaji Kazuki, Haga Yuya, Tsutsumi Yasuo
School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
ACS Nanosci Au. 2024 Aug 29;4(5):317-321. doi: 10.1021/acsnanoscienceau.4c00021. eCollection 2024 Oct 16.
Given that daily exposure to nanoparticles is now unavoidable, there are concerns that nanoparticles have unexpected biological effects due to their small size. Here, we examined the biodistribution of silver nanoparticles, which are the most frequently used nanoparticles owing to their antibacterial activity, with a diameter of 10 nm (nAg10) to the male genital tract, and the effects of paternal treatment with nAg10 on fetal development. Male Slc:ICR male mice were orally treated with nAg10 for 14 consecutive days. Inductively coupled plasma mass spectrometry analysis detected silver in the blood and testis of male mice, but no general toxicological effects were induced. Moreover, there were no significant changes in fetal development when these treated male mice were mated with nontreated female mice. This implies that although orally ingested nAg10 is distributed to the male genital tract, it does not affect fetal development under the present treatment conditions.
鉴于如今每日接触纳米颗粒已无法避免，人们担心纳米颗粒因其微小尺寸会产生意想不到的生物学效应。在此，我们研究了银纳米颗粒（因其抗菌活性而成为最常用的纳米颗粒，直径为10纳米，即nAg10）在雄性生殖道中的生物分布，以及父本用nAg10处理对胎儿发育的影响。将雄性Slc:ICR小鼠连续14天口服nAg10。电感耦合等离子体质谱分析在雄性小鼠的血液和睾丸中检测到了银，但未诱发一般毒理学效应。此外，当这些经处理的雄性小鼠与未处理的雌性小鼠交配时，胎儿发育没有显著变化。这意味着，尽管口服摄入的nAg10会分布到雄性生殖道，但在当前处理条件下它不会影响胎儿发育。
