Institute for Advanced Co-Creation Studies, Osaka University.
Graduate School of Pharmaceutical Sciences, Osaka University.
Biol Pharm Bull. 2022;45(7):806-812. doi: 10.1248/bpb.b22-00277.
Nanoparticles have a variety of useful functions. They have already been put to practical use in products in many industrial arenas, such as the cosmetics and food fields. Therefore, we cannot avoid the unintentional nanoparticle exposure of vulnerable people such as pregnant women and infants, and the importance of evaluating the safety of such vulnerable generations, who are highly sensitive to chemical substances, has been pointed out worldwide. However, it is still difficult to determine the hazards posed by nanoparticle exposure in everyday life. From this perspective, to analyze the risk from nanoparticles to vulnerable generations, nano-safety science research has been conducted through the collection of toxicity information on nanoparticles based on their physicochemical properties and kinetics via the association analysis of physicochemical properties, kinetics, and toxicity. The results of this nano-safety science research have been used in nano-safety design research to develop safer forms of nanoparticles. The findings of these studies will not only provide insights that will help us to formulate new policies for the risk management of nanoparticles; they will also lead directly to the development of sustainable nanotechnology (nanotechnology that can be safely, usefully, and sustainably used). These developments will contribute not only to the development of the nano-industry and the promotion of its social acceptance, but also to future developments in the field of health science.
纳米颗粒具有多种有用的功能。它们已经在许多工业领域的产品中得到实际应用，如化妆品和食品领域。因此，我们无法避免孕妇和婴儿等弱势群体的纳米颗粒的非故意暴露，而且全世界都已经指出，对这些对化学物质高度敏感的弱势群体进行安全评估非常重要。然而，目前仍然难以确定日常生活中纳米颗粒暴露带来的危害。从这个角度来看，为了分析纳米颗粒对弱势群体的风险，通过基于纳米颗粒理化性质和动力学的关联分析，收集纳米颗粒毒性信息，进行了纳米安全科学研究。该纳米安全科学研究的结果已用于纳米安全设计研究，以开发更安全的纳米颗粒形式。这些研究的结果不仅将提供有助于我们制定纳米颗粒风险管理新政策的见解，还将直接导致可持续纳米技术（可以安全、有用和可持续使用的纳米技术）的发展。这些发展不仅将有助于纳米产业的发展和促进其社会接受度，还将有助于健康科学领域的未来发展。
