Zheng Cheng-Chao, Gao Liang, Sun Hao, Zhao Xin-Yu, Gao Zhu-Qing, Liu Jie, Guo Wei
Fujian Provincial Geriatric Hospital, Fuzhou, China.
The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Heliyon. 2024 Sep 20;10(19):e38187. doi: 10.1016/j.heliyon.2024.e38187. eCollection 2024 Oct 15.
Enzymatic reaction-mediated microbial transformation has emerged as a promising technology with significant potential in various industries. These technologies offer the ability to produce enzymes on a large scale, optimize their functionality, and enable sustainable production processes. By utilizing microbial hosts and manipulating their genetic makeup, enzymes can be synthesized efficiently and tailored to meet specific industrial requirements. This leads to enhanced enzyme performance and selectivity, facilitating the development of novel processes and the production of valuable compounds. Moreover, microbial transformation and biosynthesis offer sustainable alternatives to traditional chemical methods, reducing environmental impact and promoting greener production practices. Microbial transformations enrich drug candidate diversity and enhance active ingredient potency, benefiting the pharmaceutical industry. Continued advancements in genetic engineering and bioprocess optimization drive further innovation and application development in Enzymatic reaction-mediated microbial transformation. The integration of AI for predicting enzymatic reactions and optimizing pathways marks a promising direction for future research. In summary, these technologies have the potential to revolutionize several industries by providing cost-effective, sustainable solutions.
酶促反应介导的微生物转化已成为一项有前途的技术,在各个行业具有巨大潜力。这些技术能够大规模生产酶,优化其功能,并实现可持续的生产过程。通过利用微生物宿主并操纵其基因组成,可以高效合成酶并使其满足特定的工业需求。这导致酶的性能和选择性增强,促进新工艺的开发和有价值化合物的生产。此外,微生物转化和生物合成提供了传统化学方法的可持续替代方案,减少了环境影响并促进了更环保的生产实践。微生物转化丰富了药物候选物的多样性并增强了活性成分的效力,使制药行业受益。基因工程和生物工艺优化的持续进步推动了酶促反应介导的微生物转化的进一步创新和应用开发。整合人工智能以预测酶促反应和优化途径是未来研究的一个有前途的方向。总之,这些技术有潜力通过提供具有成本效益的可持续解决方案来彻底改变多个行业。