恶性间皮瘤中的染色体变化。

Chromosome changes in malignant mesothelioma.

作者信息

Gibas Z, Li F P, Antman K H, Bernal S, Stahel R, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):191-201. doi: 10.1016/0165-4608(86)90074-9.

Abstract

Cytogenetic study was made of mesothelioma cells from 14 patients. Metaphases were obtained from 12 tumors and revealed aneuploidy and clonal abnormalities in 9 specimens. In the two remaining cases, no metaphases were obtained. The cytogenetic abnormalities were complex, and up to 12 marker chromosomes were observed in the tumors. Rearrangements of chromosomes #1, #2, #3, #6, #9, #11, #17, and #22 were most frequently observed. Chromosome markers involved diverse bands, including several that are loci of oncogenes, fragile sites, and nonrandom rearrangements in other types of cancer. This study shows that the karyotypes of malignant mesothelioma can be analyzed by standard cytogenetic techniques. Additional studies of untreated mesothelioma may help to distinguish primary cytogenetic changes from effects of prior therapy in some of our patients.

摘要

对14例患者的间皮瘤细胞进行了细胞遗传学研究。从12个肿瘤中获得了中期分裂相，9个标本显示出非整倍体和克隆性异常。在其余2例中，未获得中期分裂相。细胞遗传学异常很复杂，肿瘤中观察到多达12条标记染色体。1号、2号、3号、6号、9号、11号、17号和22号染色体的重排最为常见。染色体标记涉及不同的带，包括一些在其他类型癌症中是癌基因位点、脆性位点和非随机重排的带。这项研究表明，恶性间皮瘤的核型可以通过标准细胞遗传学技术进行分析。对未经治疗的间皮瘤的进一步研究可能有助于在我们的一些患者中区分原发性细胞遗传学变化和先前治疗的影响。