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全免疫炎症值在无保护左主干冠状动脉支架置入患者中的预后价值

Prognostic value of pan immune-inflammation value in patients undergoing unprotected left main coronary artery stenting.

作者信息

Karaduman Ahmet, Yılmaz Cemalettin, Keten Mustafa Ferhat, Balaban İsmail, Kültürsay Barkın, Danışman Neşri, Tiryaki Muhammet Mucahit, Alizade Elnur, Zehir Regayip

机构信息

Department of Cardiology, Kartal Kosuyolu Research & Education Hospital, Denizer Road, Cevizli Crossroads, No: 2, 34840, Kartal, Istanbul, Turkey.

Department of Cardiology, Mus State Hospital, Saltukgazi Neighborhood, Hospital Street, 49400, Malazgirt, Mus, Turkey.

出版信息

Biomark Med. 2024;18(21-22):957-967. doi: 10.1080/17520363.2024.2412515. Epub 2024 Oct 21.

Abstract

This study aimed long-term prognostic factors for percutaneous coronary intervention (PCI) in left main coronary artery (LMCA) disease, focusing on inflammatory parameters like Pan Immune-Inflammation Value (PIV) and Systemic Immune-Inflammation Index (SII). This retrospective, observational study involved 121 patients receiving unprotected LMCA PCI.The study's primary end point was MACE, including all-cause death, repeat revascularization and myocardial reinfarction. The PIV and SII scores emerged as independent predictors of MACE occurrence in patients undergoing PCI for unprotected LMCA disease (p:0.045,p:0.048;respectively).In addition, age, ejection fraction, creatinine, shock presentation and the residual syntax score were identified as significant independent predictors of MACE in both models. This study showed a significant, independent correlation between PIV, SII and MACE in patients undergoing PCI for LMCA disease, with PIV showing slightly better predictive capability than SII.

摘要

本研究旨在探讨左主干冠状动脉(LMCA)疾病经皮冠状动脉介入治疗(PCI)的长期预后因素,重点关注炎症参数,如全免疫炎症值(PIV)和全身免疫炎症指数(SII)。这项回顾性观察性研究纳入了121例接受非保护左主干冠状动脉PCI的患者。该研究的主要终点是主要不良心血管事件(MACE),包括全因死亡、再次血运重建和心肌再梗死。PIV和SII评分是接受非保护左主干冠状动脉疾病PCI患者发生MACE的独立预测因素(p值分别为0.045和0.048)。此外,在两个模型中,年龄、射血分数、肌酐、休克表现和残余SYNTAX评分均被确定为MACE的显著独立预测因素。本研究表明,在接受左主干冠状动脉疾病PCI的患者中,PIV、SII与MACE之间存在显著的独立相关性,PIV的预测能力略优于SII。

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