Karaduman Ahmet, Yılmaz Cemalettin, Keten Mustafa Ferhat, Balaban İsmail, Kültürsay Barkın, Danışman Neşri, Tiryaki Muhammet Mucahit, Alizade Elnur, Zehir Regayip
Department of Cardiology, Kartal Kosuyolu Research & Education Hospital, Denizer Road, Cevizli Crossroads, No: 2, 34840, Kartal, Istanbul, Turkey.
Department of Cardiology, Mus State Hospital, Saltukgazi Neighborhood, Hospital Street, 49400, Malazgirt, Mus, Turkey.
Biomark Med. 2024;18(21-22):957-967. doi: 10.1080/17520363.2024.2412515. Epub 2024 Oct 21.
This study aimed long-term prognostic factors for percutaneous coronary intervention (PCI) in left main coronary artery (LMCA) disease, focusing on inflammatory parameters like Pan Immune-Inflammation Value (PIV) and Systemic Immune-Inflammation Index (SII). This retrospective, observational study involved 121 patients receiving unprotected LMCA PCI.The study's primary end point was MACE, including all-cause death, repeat revascularization and myocardial reinfarction. The PIV and SII scores emerged as independent predictors of MACE occurrence in patients undergoing PCI for unprotected LMCA disease (p:0.045,p:0.048;respectively).In addition, age, ejection fraction, creatinine, shock presentation and the residual syntax score were identified as significant independent predictors of MACE in both models. This study showed a significant, independent correlation between PIV, SII and MACE in patients undergoing PCI for LMCA disease, with PIV showing slightly better predictive capability than SII.
本研究旨在探讨左主干冠状动脉(LMCA)疾病经皮冠状动脉介入治疗(PCI)的长期预后因素,重点关注炎症参数,如全免疫炎症值(PIV)和全身免疫炎症指数(SII)。这项回顾性观察性研究纳入了121例接受非保护左主干冠状动脉PCI的患者。该研究的主要终点是主要不良心血管事件(MACE),包括全因死亡、再次血运重建和心肌再梗死。PIV和SII评分是接受非保护左主干冠状动脉疾病PCI患者发生MACE的独立预测因素(p值分别为0.045和0.048)。此外,在两个模型中,年龄、射血分数、肌酐、休克表现和残余SYNTAX评分均被确定为MACE的显著独立预测因素。本研究表明,在接受左主干冠状动脉疾病PCI的患者中,PIV、SII与MACE之间存在显著的独立相关性,PIV的预测能力略优于SII。