Krawutschke Marvin, Teufel Martin, Schmidt Kira, Pasche Saskia, Schweig Theresa, Bialek Anna, Kowalski Axel, Tewes Mitra, Schuler Martin, Schadendorf Dirk, Scherbaum Norbert, Skoda Eva-Maria, Fink Madeleine, Müller Bernhard W
Clinic for Psychosomatic Medicine and Psychotherapy, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Clin EEG Neurosci. 2025 May;56(3):217-229. doi: 10.1177/15500594241287961. Epub 2024 Oct 21.
Electroencephalographic neurofeedback (EEG NF) or its effects on event-related potentials (ERPs) in quantitative EEG have not yet been systematically studied in cancer patients. The aim of this study was to investigate the emotional arousal and valence effects on the event-related P300 in a visual oddball paradigm by an individualized EEG alpha and theta/beta NF intervention in cancer patients and survivors (= 18, age between 31 and 73 years). . ERPs to low and high arousal target stimuli with either emotional positive or negative content and depressive state were obtained in cancer patients before and after a five-week NF intervention in a waitlist paradigm, following the consensus on the reporting and experimental design of clinical and cognitive-behavioral NF studies (CRED-nf checklist). . Overall, P300 amplitudes decreased significantly (< .05) from pre to post therapy. Effects concerning high arousal stimuli with negative and positive valences were on the border to significance. Moreover, patients achieved significant relief of depressive symptoms (< .05). Especially younger participants (<55 yrs.) benefited. . P300 observations could reflect a therapeutic effect on brain activity level. EEG NF alleviates depressive symptoms in cancer patients. . Based on these findings, further studies are needed to investigate the effects on event-related potentials by NF therapy.
脑电图神经反馈（EEG NF）及其对癌症患者定量脑电图中事件相关电位（ERP）的影响尚未得到系统研究。本研究的目的是通过对癌症患者和幸存者（=18名，年龄在31至73岁之间）进行个性化的脑电图α和θ/β神经反馈干预，研究视觉Oddball范式中情绪唤醒和效价对事件相关P300的影响。在等待名单范式下，对癌症患者进行为期五周的神经反馈干预前后，根据临床和认知行为神经反馈研究报告和实验设计的共识（CRED-nf清单），获得对具有情绪积极或消极内容以及抑郁状态的低唤醒和高唤醒目标刺激的ERP。总体而言，治疗前到治疗后P300波幅显著降低（<0.05）。关于具有负性和正性效价的高唤醒刺激的影响接近显著水平。此外，患者的抑郁症状得到显著缓解（<0.05）。尤其是年轻参与者（<55岁）受益。P300观察结果可能反映了对大脑活动水平的治疗效果。脑电图神经反馈可缓解癌症患者的抑郁症状。基于这些发现，需要进一步研究来调查神经反馈疗法对事件相关电位的影响。
