Schweig Theresa, Fink Madeleine, Schmidt Kira, Krawutschke Marvin, Pasche Saskia, Skoda Eva-Maria, Teufel Martin, Müller Bernhard W
University of Duisburg-Essen, Essen, Germany.
University Hospital Essen, Essen, Germany.
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241294057. doi: 10.1177/15347354241294057.
The aim of this study was to investigate changes in P3 amplitude and latency to emotional stimuli with different arousal and valence levels after a mindfulness-based intervention in oncological patients. P3 amplitude and latency at Fz, Cz, and Pz to emotional salient stimuli differing in valence (positive vs. negative) and arousal (low vs. high) levels were measured in 17 oncological patients ( = 51 years, SD = 9.17, females = 11) before and after a mindfulness-based intervention in a waitlist-controlled clinical trial. Group sessions were held 2x/week over a period of 5 weeks. Arousal and valence levels of emotional salient stimuli were significant modulators of P3 amplitudes ( = .050; = .006, respectively). P3 amplitudes at Fz decreased significantly from pre-waitlist to post-intervention ( = .002). P3 latency for negatively valenced stimuli decreased from pre- to post-intervention with trending significance ( = .080). P3 latency at Pz showed a trend of being shorter than P3 latency at Cz ( = .066). Depressive symptoms showed a decreasing trend from pre- to post-treatment ( = .075). We could show that arousal and valence levels of emotional salient stimuli are important modulators of P3 amplitudes and latencies in oncological patients. P3 amplitudes at Fz decreased significantly from pre-waitlist until after mindfulness-based intervention, decreases from pre-to post-intervention were linear, but not significant. In oncological patients the mindfulness-based intervention seems to have its strongest effect on the frontal electrode Fz, not the electrode Pz where its amplitude was largest. Depressive symptoms could be reduced.
本研究旨在调查在肿瘤患者中进行基于正念的干预后，不同唤醒水平和效价水平的情绪刺激下P3波幅和潜伏期的变化。在一项等待名单对照的临床试验中，对17名肿瘤患者（平均年龄=51岁，标准差=9.17，女性11名）在基于正念的干预前后，测量其在Fz、Cz和Pz电极处对效价（正性与负性）和唤醒水平（低与高）不同的情绪显著刺激的P3波幅和潜伏期。小组会议每周举行2次，为期5周。情绪显著刺激的唤醒水平和效价水平是P3波幅的显著调节因素（分别为P=0.050；P=0.006）。从等待名单前到干预后，Fz电极处的P3波幅显著降低（P=0.002）。负性效价刺激的P3潜伏期从干预前到干预后有所降低，具有趋势性显著（P=0.080）。Pz电极处的P3潜伏期显示出比Cz电极处的P3潜伏期更短的趋势（P=0.066）。抑郁症状从治疗前到治疗后呈下降趋势（P=0.075）。我们可以表明，情绪显著刺激的唤醒水平和效价水平是肿瘤患者P3波幅和潜伏期的重要调节因素。从等待名单前到基于正念的干预后，Fz电极处的P3波幅显著降低，从干预前到干预后的降低呈线性，但不显著。在肿瘤患者中，基于正念的干预似乎对额部电极Fz的影响最大，而不是对波幅最大的电极Pz。抑郁症状可以得到减轻。
