Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Nano Lett. 2024 Oct 30;24(43):13851-13860. doi: 10.1021/acs.nanolett.4c04609. Epub 2024 Oct 21.
Nanomedicines have been widely used in colorectal cancer treatment, but their suboptimal targeting and deficient penetration capabilities remain obstacles in the delivery of therapeutics. In this study, inspired by the natural tumor tropism and intestinal invasion of , we engineered highly biomimetic nanoparticles (SM-AuNRs) utilizing a membrane to coat bacilliform Au nanorods. The engineered SM-AuNRs were able to mimic the germ's morphology and biological surface. SM-AuNRs containing the specific proteins inherited from the membrane facilitated specific targeting and internalization into tumor cells. Meanwhile, SM-AuNRs with the rod-shaped morphology effectively traversed mucus barriers and tumor stroma. Due to the superior biological barrier penetrating and tumor targeting capabilities, doxorubicin-loaded SM-AuNRs with near-infrared laser irradiation displayed remarkable photothermal-chemotherapeutic antitumor effects in mouse orthotopic colorectal cancer models. Our findings pave the way for the design of bacteria-mimicking nanoparticles, presenting a promising avenue for the targeting and efficient treatment of colorectal cancer.
纳米药物已广泛应用于结直肠癌的治疗，但它们靶向性差和穿透能力不足仍然是治疗药物传递的障碍。在这项研究中，我们受 的天然肿瘤趋向性和肠道侵袭性的启发，利用 膜来包覆棒状金纳米棒，设计了高度仿生的纳米颗粒（SM-AuNRs）。工程化的 SM-AuNRs 能够模拟细菌的形态和生物表面。含有 膜遗传的特定蛋白的 SM-AuNRs 有助于特异性靶向和内化进入肿瘤细胞。同时，具有棒状形态的 SM-AuNRs 能够有效地穿透黏液屏障和肿瘤基质。由于具有优异的生物屏障穿透和肿瘤靶向能力，负载多柔比星的 SM-AuNRs 在近红外激光照射下，在小鼠原位结直肠癌模型中显示出显著的光热-化学治疗抗肿瘤效果。我们的研究结果为设计细菌模拟纳米颗粒铺平了道路，为结直肠癌的靶向治疗和高效治疗提供了有前途的途径。
