Wu Shida, Wang Kuiyou, Lv Qiyan, Tan Mingqian
State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian, Liaoning 116034, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, Liaoning 116034, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian, Liaoning 116034, China; Dalian Key Laboratory for Precision Nutrition, Dalian Polytechnic University, Dalian, Liaoning 116034, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114325. doi: 10.1016/j.colsurfb.2024.114325. Epub 2024 Oct 16.
The macula, a small but highly important area in the retina, is crucial for healthy vision. Age-related macular degeneration is responsible for approximately 8.7 % of blindness worldwide, and affected individuals are burgeoning. The age-related macular degeneration is often triggered by oxidative stress and excessive inflammation that damage the retinal pigment epithelial cells in the macula. Curcumin, a potent antioxidant and anti-inflammatory carotenoid, is hampered by low compatibility and stability issues in food science. Innovatively, this study harnessed milk-derived exosomes as a novel delivery method yielding a curcumin-infused system (curcumin@exosome) to increase its biocompatibility and stability. This fusion not only curbed excessive reactive oxygen species but also neutralized HO-induced mitochondrial disruption in cellular models. It revitalized retinal pigment epithelial cells, reverting their function near to baseline in vitro. The curcumin@exosome outshined in subduing pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β induced by sodium iodate. This study illuminates that the curcumin@exosome is promise as a therapeutic intervention for retinal ailments marked by oxidative and inflammatory distress.
黄斑是视网膜中一个小但非常重要的区域，对健康视力至关重要。年龄相关性黄斑变性导致全球约8.7%的失明，且受影响个体数量正在迅速增加。年龄相关性黄斑变性通常由氧化应激和过度炎症引发，这些会损害黄斑中的视网膜色素上皮细胞。姜黄素是一种有效的抗氧化和抗炎类胡萝卜素，但在食品科学中存在低相容性和稳定性问题。本研究创新性地利用牛奶来源的外泌体作为一种新型递送方法，构建了一种注入姜黄素的系统（姜黄素@外泌体），以提高其生物相容性和稳定性。这种融合不仅抑制了过量的活性氧，还中和了细胞模型中过氧化氢诱导的线粒体破坏。它使视网膜色素上皮细胞恢复活力，在体外使其功能恢复到接近基线水平。姜黄素@外泌体在抑制碘酸钠诱导的促炎细胞因子肿瘤坏死因子-α和白细胞介素-1β方面表现出色。本研究表明，姜黄素@外泌体有望作为一种治疗干预手段，用于治疗以氧化和炎症应激为特征的视网膜疾病。
