仓鼠棕色脂肪组织线粒体对芥酰肉碱抑制的部分保护作用归因于高辅酶A水平：与大鼠棕色脂肪组织线粒体的比较。

Partial protection against erucoyl-carnitine inhibition in hamster brown-adipose-tissue mitochondria is due to high CoA levels: a comparison with rat brown-adipose-tissue mitochondria.

作者信息

Alexson S, Nedergaard J, Cannon B

出版信息

Comp Biochem Physiol B. 1986;83(1):191-6. doi: 10.1016/0305-0491(86)90352-4.

Abstract

Brown-adipose-tissue mitochondria isolated from golden hamsters were found to contain more CoA per mg protein than rat brown-fat mitochondria, and after incubation with erucoyl-carnitine, a higher free CoA level remained, than in rat mitochondria. In accordance with the suggestion (Alexson et al. (1985) Biochim. biophys. Acta 834, 149-158) that the inhibitory effect of erucoyl-carnitine on brown-fat mitochondrial respiration is entirely due to CoA sequestration, hamster mitochondria (with more CoA) were less sensitive to erucoyl inhibition than were rat mitochondria. Thus, increased mitochondrial CoA levels may augment the ability of animals to withstand the detrimental effects of a high erucoyl ester content of the diet.

摘要

从金黄地鼠分离出的棕色脂肪组织线粒体，每毫克蛋白质所含的辅酶A比大鼠棕色脂肪线粒体更多。在用芥酸肉碱孵育后，其游离辅酶A水平比大鼠线粒体中的更高。根据Alexson等人（1985年，《生物化学与生物物理学报》834卷，第149 - 158页）提出的芥酸肉碱对棕色脂肪线粒体呼吸的抑制作用完全是由于辅酶A被隔离的观点，仓鼠线粒体（含有更多辅酶A）对芥酸抑制的敏感性低于大鼠线粒体。因此，线粒体辅酶A水平的升高可能增强动物抵御高芥酸酯含量饮食有害影响的能力。