Department of Urology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai Jiao Tong University, Shanghai 200233, People's Republic of China.
Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, United States of America.
Biofabrication. 2024 Nov 1;17(1). doi: 10.1088/1758-5090/ad8965.
Urethral strictures are common in urology; however, the reconstruction of long urethral strictures remains challenging. There are still unavoidable limitations in the clinical application of grafts for urethral injuries, which has facilitated the advancement of urethral tissue engineering. Tissue-engineered urethral scaffolds that combine cells or bioactive factors with a biomaterial to mimic the native microenvironment of the urethra, offer a promising approach to urethral reconstruction. Despite the recent rapid development of tissue engineering materials and techniques, a consensus on the optimal strategy for urethral repair and reconstruction is still lacking. This review aims to collect the achievements of urethral tissue engineering in recent years and to categorize and summarize them to shed new light on their design. Finally, we visualize several important future directions for urethral repair and reconstruction.
尿道狭窄在泌尿科中很常见；然而，长段尿道狭窄的重建仍然具有挑战性。移植物在尿道损伤中的临床应用仍然存在不可避免的局限性，这促进了尿道组织工程的发展。将细胞或生物活性因子与生物材料结合起来，模拟尿道的天然微环境的组织工程尿道支架，为尿道重建提供了一种很有前途的方法。尽管近年来组织工程材料和技术发展迅速，但对于尿道修复和重建的最佳策略仍缺乏共识。本综述旨在收集近年来尿道组织工程的研究成果，并对其进行分类和总结，以期为其设计提供新的思路。最后，我们展望了尿道修复和重建的几个重要的未来方向。
