足月胎儿肝细胞中葡萄糖和酮体的生成——II. 母体肾上腺切除术的影响

Glucose and ketone bodies production in hepatocytes isolated from fetuses at term--II. Effect of maternal adrenalectomy.

作者信息

Arahuetes R M, López J, Ramos M

出版信息

Comp Biochem Physiol B. 1986;83(1):231-3. doi: 10.1016/0305-0491(86)90358-5.

Abstract

Glucose and ketone bodies production has been studied in hepatocytes isolated from fetuses at term of fed and fasted adrenalectomized mothers. Maternal adrenalectomy diminishes the fetal liver weight. This effect is increased when the adrenalectomized pregnant rat is fasted for the last 2 days of gestation. Maternal adrenalectomy diminishes glucose production in hepatocytes isolated from fetuses at term. This diminution is markedly greater when the adrenalectomized pregnant rat is fasted for the last 48 hr of gestation. Maternal adrenalectomy diminishes ketone bodies production in hepatocytes isolated from fetuses at term.

摘要

已经对从足月喂食和禁食的肾上腺切除的母亲所产胎儿中分离出的肝细胞中的葡萄糖和酮体生成进行了研究。母体肾上腺切除术会使胎儿肝脏重量减轻。当肾上腺切除的怀孕大鼠在妊娠的最后2天禁食时，这种影响会增强。母体肾上腺切除术会减少从足月胎儿中分离出的肝细胞中的葡萄糖生成。当肾上腺切除的怀孕大鼠在妊娠的最后48小时禁食时，这种减少会明显更大。母体肾上腺切除术会减少从足月胎儿中分离出的肝细胞中的酮体生成。