Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Nutrition Science and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr J. 2024 Oct 21;23(1):127. doi: 10.1186/s12937-024-01028-x.
Dietary patterns and lifestyle factors can influence the intensity of systemic inflammation and, consequently, the development and progression of coronary artery calcification (CAC). This study aimed to explore the relationship between the inflammatory potentials of diet and lifestyle, as captured by novel dietary and lifestyle inflammation scores (DIS and LIS), with CAC incidence and progression.
We analyzed data on 5949 Black and White men and women ≥ 45 years old participating in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Baseline data on diet and lifestyle factors were collected from 2000 to 2002 and used to construct the DIS and LIS, which reflect the overall inflammatory potential of diet and lifestyle. Cox proportional hazard regression was used to calculate the hazard ratios (HR) and 95% confidence intervals (95% CI) for CAC incidence and progression across quartiles of DIS and LIS, adjusting for potential confounders.
Over a median follow-up of 8.0 years, among 2638 participants with zero CAC score at baseline, 977 individuals developed positive scores, and 1681 out of 2561 participants showed CAC progression. For individuals in the highest (more pro-inflammatory) compared to the lowest (more anti-inflammatory) quartiles of the LIS, the multivariable-adjusted HR for CAC incidence was 1.35 (95% CI, 1.10-1.65; P trend < 0.002). This association was stronger among younger adults aged < 60 years compared to those aged ≥ 60 years, with respective values of 1.76 (1.34-2.30) and 1.02 (0.78-1.35) (P interaction < 0.001). However, the LIS was not significantly associated with the progression of existing CAC. Among the components of the LIS, a body mas index (BMI) ≥ 25 kg/m and current smoking were significant predictors for the incidence and progression of CAC, respectively. No significant association was found between DIS and CAC incidence and progression.
Lifestyle factors, through their impact on systemic inflammation, may be associated with a higher risk of CAC incidence in middle and late adulthood.
饮食模式和生活方式因素会影响全身炎症的程度，从而影响冠状动脉钙化（CAC）的发生和发展。本研究旨在探讨饮食和生活方式的炎症潜力与 CAC 发病和进展之间的关系。
我们分析了 5949 名≥45 岁的黑人和白人参与多民族动脉粥样硬化研究（MESA）队列的数据。2000 年至 2002 年收集了饮食和生活方式因素的基线数据，并用于构建反映饮食和生活方式整体炎症潜力的饮食和生活方式炎症评分（DIS 和 LIS）。使用 Cox 比例风险回归计算了 DIS 和 LIS 四分位数与 CAC 发病和进展相关的风险比（HR）和 95%置信区间（95%CI），并调整了潜在混杂因素。
在中位随访 8.0 年期间，在基线时无 CAC 评分的 2638 名参与者中，有 977 名发展为阳性评分，在 2561 名有 CAC 进展的参与者中，有 1681 名进展。与 LIS 最低四分位数（更抗炎）相比，LIS 最高四分位数（更促炎）个体的 CAC 发病的多变量调整 HR 为 1.35（95%CI，1.10-1.65；P 趋势<0.002）。在年龄<60 岁的年轻人中，这种相关性更强，分别为 1.76（1.34-2.30）和 1.02（0.78-1.35）（P 交互<0.001）。然而，LIS 与现有 CAC 的进展无显著相关性。在 LIS 的组成部分中，BMI≥25 kg/m2 和当前吸烟分别是 CAC 发病和进展的显著预测因素。DIS 与 CAC 发病和进展之间无显著相关性。
生活方式因素通过影响全身炎症，可能与中年和晚年 CAC 发病风险的增加有关。
