Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr J. 2023 Jan 7;22(1):1. doi: 10.1186/s12937-023-00835-y.
Systemic inflammation can be the initiator in developing chronic diseases that may be affected by the lifestyle and diet of individuals. In the current study, we aimed to assess the association of the inflammatory potential of diet and lifestyle, determined by the food-based index of dietary inflammatory potential (FBDI), dietary inflammation score (DIS), and lifestyle inflammation score (LIS), with risk of chronic kidney disease(CKD) in Iranian adults.
A total of 6044 CKD-free individuals aged ≥ 18 years, were recruited from among participants of the Tehran Lipid and Glucose Study(surveys 3 and 4) and followed a mean of 6.03 years(follow-up rate:94.95%). Data on dietary intakes were determined using a food frequency questionnaire. The inflammatory potential of diet and lifestyle were determined based on three indices, including FBDI, DIS, and LIS. Using the National Kidney Foundation guidelines, we defined CKD as eGFR < 60 mL/min/1.73 m.
Mean ± SD age of the study population(54.3% women) was 37.8 ± 12.8 years. We identified 1216(20.1%) new cases of CKD during the 6.03 years of follow-up (46,889.8 person-years). In the multivariable-adjusted model, the risk of CKD incident is increased across quartiles of FBDI (HR = 1.21;95%CI:1.03-1.42, P:0.014) and LIS (HR = 1.28;95%CI:1.07-1.55,P:0.006). However, no significant relationship was observed between the higher DIS score and CKD risk.
Our findings showed that a higher inflammatory potential of diet and lifestyle, characterized by a higher score of FBDI and LIS, was related to increased incidence of CKD, while no significant relationship was reported between the DIS score and CKD incident.
系统性炎症可能是导致慢性疾病的诱因，而这些慢性疾病可能受到个体生活方式和饮食习惯的影响。在本研究中，我们旨在评估饮食和生活方式的炎症潜能，由基于食物的饮食炎症潜能指数（FBDI）、饮食炎症评分（DIS）和生活方式炎症评分（LIS）来确定，与伊朗成年人慢性肾病（CKD）风险的关系。
共纳入 6044 名无 CKD 的年龄≥18 岁的个体，他们来自 Tehran Lipid and Glucose Study（调查 3 和 4）的参与者，并随访了平均 6.03 年（随访率：94.95%）。通过食物频率问卷来确定饮食摄入量的数据。基于三种指数，包括 FBDI、DIS 和 LIS，来确定饮食和生活方式的炎症潜能。根据美国国家肾脏病基金会的指南，我们将 CKD 定义为 eGFR<60 mL/min/1.73 m。
研究人群（54.3%为女性）的平均年龄（±标准差）为 37.8±12.8 岁。在 6.03 年的随访期间，共发现 1216 例（20.1%）新的 CKD 病例（46889.8 人年）。在多变量调整模型中，FBDI 的四分位距增加与 CKD 发病风险呈正相关（HR=1.21；95%CI：1.03-1.42，P=0.014）和 LIS（HR=1.28；95%CI：1.07-1.55，P=0.006）。然而，较高的 DIS 评分与 CKD 风险之间没有显著的关系。
我们的研究结果表明，饮食和生活方式的炎症潜能较高，其特征为 FBDI 和 LIS 评分较高，与 CKD 的发病率增加有关，而 DIS 评分与 CKD 发病之间没有显著的关系。
