Ito Yutaro, Nagasawa Miho, Koyama Kahori, Ito Kohei, Kikusui Takefumi
BIOTA Inc., Tokyo, Japan.
Laboratory of Human-Animal Interaction and Reciprocity, Department of Animal Science and Biotechnology, Azabu University, Kanagawa, Japan.
Front Vet Sci. 2024 Oct 7;11:1417461. doi: 10.3389/fvets.2024.1417461. eCollection 2024.
The One Health concept is a comprehensive understanding of the interaction between humans, animals, and the environment. The cohabitation of humans and pets positively affects their physical, mental, and social well-being. It is recognized as an essential factor from the One Health perspective. Furthermore, a healthy balance in the gut microbiome is essential for good health, and the changes in the gut microbiome associated with cohabitation between humans and pets could potentially affect various aspects of the health of both hosts. Therefore, elucidating the sharing of gut bacteria between humans and pets associated with cohabitation is important for understanding One Health. However, most studies have examined sharing at the taxonomic level, and it remains unclear whether the same bacteria are transferred between humans and pets, and whether they mutually influence each other.
Here, microbiome analysis and shared 16S rRNA gene amplicon sequence variant (ASV) analysis were conducted before the start of cohabitation between humans and dogs, as well as at 2 weeks, 1 month, and 3 months after cohabitation.
16S rRNA gene ASVs analysis indicated that gut microbes have been transferred between humans and dogs. The overall structure of the gut microbiota within human-dog pairs remained unchanged after 3 months of adaptation. However, 11ASVs were shared within human-dog pairs. Many shared ASVs were highly abundant within each host, and this high abundance may be considered a factor that influences bacterial transfer between hosts.
Our results provide important insights into the potential for the transfer of gut bacteria between humans and dogs. These findings are considered crucial for understanding the impact of human-dog cohabitation on various aspects of health.
“同一健康”概念是对人类、动物和环境之间相互作用的全面理解。人类与宠物共同生活对他们的身心健康和社会福祉有积极影响。从“同一健康”的角度来看，这被认为是一个重要因素。此外，肠道微生物群的健康平衡对良好健康至关重要，与人类和宠物共同生活相关的肠道微生物群变化可能会影响宿主双方健康的各个方面。因此，阐明与共同生活相关的人类和宠物之间肠道细菌的共享情况对于理解“同一健康”很重要。然而，大多数研究都在分类学水平上研究了共享情况，人类和宠物之间是否转移了相同的细菌以及它们是否相互影响仍不清楚。
在这里，在人类与狗开始共同生活之前以及共同生活后2周、1个月和3个月进行了微生物群分析和共享的16S rRNA基因扩增子序列变体（ASV）分析。
16S rRNA基因ASV分析表明，肠道微生物已在人类和狗之间转移。经过3个月的适应，人狗配对中肠道微生物群的整体结构保持不变。然而，人狗配对中有11个ASV是共享的。许多共享的ASV在每个宿主中都高度丰富，这种高丰度可能被认为是影响宿主间细菌转移的一个因素。
我们的结果为人类和狗之间肠道细菌转移的可能性提供了重要见解。这些发现被认为对于理解人狗共同生活对健康各个方面的影响至关重要。
