Xia Yu, Wu Yadong, Yin Xinhai, Song Jukun
Department of Oral Medicine Guizhou Provincial People's Hospital Guiyang China.
Department of Oral and Maxillofacial Surgery the Affiliated Stomatological Hospital of Guizhou Medical University Guiyang China.
Health Sci Rep. 2024 Oct 21;7(10):e70103. doi: 10.1002/hsr2.70103. eCollection 2024 Oct.
This study explores the possible connection between periodontitis and gut microbiota in East Asians, a relationship that has been largely unexplored until now.
Using publicly available genome-wide association study (GWAS) data, we performed Mendelian randomization (MR). We analyzed GWAS summary statistics to assess if gut microbiota could causally influence periodontitis risk. We applied methods such as MR-Egger, weighted median, inverse variance weighting, and simple MR, and conducted sensitivity analyses to confirm our findings.
Utilizing the Inverse-Variance Weighted approach, we identified potential causal relationships between 17 host-genetically influenced gut microbiota characteristics and periodontitis, including , , and . Specifically, was linked to an increased risk of periodontitis (odds ratios [OR] 1.07, 95% confidence interval [CI] 1.02-1.15, = 0.0004), while was linked to a decreased likelihood of tooth loss (OR 0.98, 95% CI 0.96-0.99, = 0.0005). No evidence of pleiotropy or heterogeneity was observed across sensitivity analyses.
This study reveals a causal relationship between specific microorganisms and periodontitis in the Asian population, shedding light on the influence of gut microbiota on periodontitis.
本研究探讨东亚人群中牙周炎与肠道微生物群之间可能存在的联系，这种关系迄今为止在很大程度上尚未得到探索。
利用公开可用的全基因组关联研究（GWAS）数据，我们进行了孟德尔随机化（MR）分析。我们分析了GWAS汇总统计数据，以评估肠道微生物群是否会因果性地影响牙周炎风险。我们应用了MR-Egger、加权中位数、逆方差加权和简单MR等方法，并进行了敏感性分析以证实我们的发现。
利用逆方差加权方法，我们确定了17种受宿主基因影响的肠道微生物群特征与牙周炎之间的潜在因果关系，包括[此处原文缺失具体内容]、[此处原文缺失具体内容]和[此处原文缺失具体内容]。具体而言，[此处原文缺失具体内容]与牙周炎风险增加相关（优势比[OR]1.07，95%置信区间[CI]1.02 - 1.15，P = 0.0004），而[此处原文缺失具体内容]与牙齿脱落可能性降低相关（OR 0.98，95% CI 0.96 - 0.99，P = 0.0005）。在敏感性分析中未观察到多效性或异质性的证据。
本研究揭示了亚洲人群中特定微生物与牙周炎之间的因果关系，阐明了肠道微生物群对牙周炎的影响。
