Deshpande Prajakta, Chimata Anuradha Venkatakrishnan, Singh Amit
Department of Biology, University of Dayton, Dayton, OH, USA.
Premedical Program, University of Dayton, Dayton, OH, USA.
Neural Regen Res. 2025 Oct 1;20(10):2862-2871. doi: 10.4103/NRR.NRR-D-24-00779. Epub 2024 Oct 22.
Acetyltransferases, required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease. Protein acetylation is a common post-translational modification pivotal to basic cellular processes. Close to 80%-90% of proteins are acetylated during translation, which is an irreversible process that affects protein structure, function, life, and localization. In this review, we have discussed the various N-acetyltransferases present in humans, their function, and how they might play a role in diseases. Furthermore, we have focused on N-acetyltransferase 9 and its role in microtubule stability. We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases. We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.
将乙酰基转移至蛋白质上所必需的乙酰转移酶是高度保守的蛋白质，在发育和疾病中起着至关重要的作用。蛋白质乙酰化是一种常见的翻译后修饰，对基本细胞过程至关重要。接近80%-90%的蛋白质在翻译过程中被乙酰化，这是一个不可逆的过程，会影响蛋白质的结构、功能、寿命和定位。在这篇综述中，我们讨论了人类中存在的各种N-乙酰转移酶、它们的功能以及它们在疾病中可能发挥的作用。此外，我们重点关注了N-乙酰转移酶9及其在微管稳定性中的作用。我们阐明了N-乙酰转移酶9和蛋白质乙酰化如何可能在神经退行性疾病中发挥作用。我们特别讨论了N-乙酰转移酶9在发育和神经退行性变过程中对c-Jun氨基末端激酶信号传导和微管稳定性的非乙酰化依赖性功能及调控。
