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多房棘球绦虫:蒙古沙鼠对感染的反应

Echinococcus multilocularis: responses to infection in Mongolian gerbils.

作者信息

Kroeze W K, Tanner C E

出版信息

Exp Parasitol. 1986 Feb;61(1):1-9. doi: 10.1016/0014-4894(86)90128-1.

DOI:10.1016/0014-4894(86)90128-1
PMID:3943584
Abstract

Mongolian gerbils (Meriones unguiculatus) inoculated intraperitoneally with three acephalic cysts of Echinococcus multilocularis were very susceptible to infection. Aspects of the responses of gerbils to this infection were examined to determine if they could be related to the progress of the infection. Hematologic changes observed during the infection included anemia, reticulocytosis, lymphocytopenia, neutrophilia, monocytosis, and eosinopenia; these changes were related to the size of the infection. Infected gerbils also produced specific protein-A binding antibodies to E. multilocularis. At 14 weeks after inoculation, infected gerbils showed splenomegaly and somewhat elevated serum transaminase levels, although serum 5'-nucleotidase levels were normal.

摘要

经腹腔接种三个多房棘球绦虫无头囊的蒙古沙鼠(长爪沙鼠)对感染非常敏感。研究了沙鼠对这种感染的反应情况,以确定这些反应是否与感染进程有关。感染期间观察到的血液学变化包括贫血、网织红细胞增多、淋巴细胞减少、嗜中性粒细胞增多、单核细胞增多和嗜酸性粒细胞减少;这些变化与感染的程度有关。受感染的沙鼠还产生了针对多房棘球绦虫的特异性蛋白A结合抗体。接种后14周,受感染的沙鼠出现脾肿大,血清转氨酶水平略有升高,不过血清5'-核苷酸酶水平正常。

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Echinococcus multilocularis: responses to infection in Mongolian gerbils.多房棘球绦虫:蒙古沙鼠对感染的反应
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引用本文的文献

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Echinococcus multilocularis: immunological study on the "Em2-positive" laminated layer during in vitro and in vivo post-oncospheral and larval development.多房棘球绦虫:对体外和体内原头蚴及幼虫发育过程中“Em2阳性”分层膜的免疫学研究
Parasitol Res. 1992;78(4):291-7. doi: 10.1007/BF00937086.