Penner E
Gastroenterology. 1986 Mar;90(3):724-7. doi: 10.1016/0016-5085(86)91129-7.
We have previously demonstrated circulating and tissue-fixed immune complexes containing the small cytoplasmic ribonucleoprotein antigen Ro and immunoglobulin G (IgG) in a case of sicca syndrome associated with primary biliary cirrhosis. To establish the overall prevalence of such complexes in liver disease, we performed dissociation experiments under conditions of Ro antigen excess. Of the diseases tested, Ro-containing immune complexes were restricted to cases with primary biliary cirrhosis. Sera from 29 of the 47 patients with primary biliary cirrhosis (60%) showed IgG-containing immune complexes; 10 of the 29 sera samples (34%) positive for IgG-containing immune complexes exhibited immune complexes composed of Ro and anti-Ro IgG. These complexes sedimented predominantly as intermediate or large aggregates and were encountered most frequently in cases with extra-hepatic features.
我们之前已证实在一例伴有原发性胆汁性肝硬化的干燥综合征病例中，存在含有小细胞质核糖核蛋白抗原Ro和免疫球蛋白G（IgG）的循环免疫复合物和组织固定免疫复合物。为确定此类复合物在肝病中的总体患病率，我们在Ro抗原过量的条件下进行了解离实验。在所检测的疾病中，含Ro免疫复合物仅限于原发性胆汁性肝硬化病例。47例原发性胆汁性肝硬化患者中有29例（60%）的血清显示含IgG免疫复合物；在这29份含IgG免疫复合物呈阳性的血清样本中，有10份（34%）呈现由Ro和抗Ro IgG组成的免疫复合物。这些复合物主要以中等或大聚集体形式沉淀，并且在具有肝外表现的病例中最为常见。
