Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Clin Chim Acta. 2025 Jan 15;565:120011. doi: 10.1016/j.cca.2024.120011. Epub 2024 Oct 20.
Ovarian cancer (OC) remains a significant women's health concern due to its high mortality rate and the challenges posed by late detection. Exploring novel biomarkers could lead to earlier, more specific diagnoses and improved survival rates for OC patients. This review focuses on biomarkers associated with extracellular vesicles (EVs) found in various proximal fluids, including urine, ascites, utero-tubal lavage fluid of OC patients. We highlight these proximal fluids as rich sources of potential biomarkers. The review explains the roles of EV biomarkers in ovarian cancer progression and discusses EV-related proteins and miRNAs as potential diagnostic or prognostic indicators and therapeutic targets. Finally, we highlighted the limitations of examining proximal fluids as sources of biomarkers and encourage researchers to proactively pursue innovative solutions to overcome these challenges.
卵巢癌（OC）仍然是一个严重的妇女健康问题，因为其死亡率高，且晚期检测困难。探索新的生物标志物可以实现 OC 患者更早、更特异性的诊断和提高生存率。本综述重点介绍了与各种近端体液（包括尿液、腹水、OC 患者的输卵管灌洗液）中发现的细胞外囊泡（EVs）相关的生物标志物。我们强调这些近端体液是潜在生物标志物的丰富来源。本综述解释了 EV 生物标志物在卵巢癌进展中的作用，并讨论了 EV 相关蛋白和 miRNA 作为潜在的诊断或预后指标和治疗靶点。最后，我们强调了检查近端体液作为生物标志物来源的局限性，并鼓励研究人员积极寻求创新解决方案来克服这些挑战。
