Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Zhejiang Provincial Clinical Research Center for CANCER, Hangzhou, Zhejiang, 310009, China.
Mol Cancer. 2024 Sep 16;23(1):201. doi: 10.1186/s12943-024-02103-x.
Ovarian cancer (OC) is one of the most prevalent and lethal gynecological malignancies, with high mortality primarily due to its aggressive nature, frequent metastasis, and resistance to standard therapies. Recent research has highlighted the critical role of extracellular vesicles (EVs) in these processes. EVs, secreted by living organisms and carrying versatile and bioactive cargoes, play a vital role in intercellular communication. Functionally, the transfer of cargoes orchestrates multiple processes that actively affect not only the primary tumor but also local and distant pre-metastatic niche. Furthermore, their unique biological properties position EVs as novel therapeutic targets and promising drug delivery systems, with potential profound implications for cancer patients.This review summarizes recent progress in EV biology, delving into the intricate mechanisms by which EVs contribute to OC metastasis and drug resistance. It also explores the latest advances and therapeutic potential of EVs in the clinical context of OC. Despite the progress made, EV research in OC remains in its nascent stages. Consequently, this review presents existing research limitations and suggests avenues for future investigation. Altogether, the review aims to elucidate the critical roles of EVs in OC and spotlight their promising potential in this field.
卵巢癌（OC）是最常见和最致命的妇科恶性肿瘤之一，其死亡率高主要是由于其侵袭性、频繁转移和对标准治疗的耐药性。最近的研究强调了细胞外囊泡（EVs）在这些过程中的关键作用。EVs 是由生物体分泌的，携带多样且具有生物活性的货物，在细胞间通讯中发挥着至关重要的作用。从功能上讲，货物的转移协调了多个过程，这些过程不仅积极影响原发性肿瘤，还影响局部和远处的转移前生态位。此外，它们独特的生物学特性使 EVs 成为新型治疗靶点和有前途的药物递送系统，对癌症患者具有深远的影响。
本综述总结了 EV 生物学的最新进展，深入探讨了 EV 促进 OC 转移和耐药性的复杂机制。它还探讨了 EV 在 OC 临床背景下的最新进展和治疗潜力。尽管已经取得了进展，但 OC 中的 EV 研究仍处于起步阶段。因此，本综述提出了现有研究的局限性，并为未来的研究提供了方向。总的来说，本综述旨在阐明 EV 在 OC 中的关键作用，并强调它们在该领域的有前途的潜力。
