小鼠大脑中少突胶质前体细胞的衰老与衰老命运

Gomez Paul T, Carver Chase M, Rodriguez Sonia L, Wang Liguo, Zhang Xu, Schafer Marissa J

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

NPJ Aging. 2024 Oct 22;10(1):47. doi: 10.1038/s41514-024-00176-y.

Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria OPCs possess niche-specific properties, compared to hippocampal OPCs. Aged fimbria OPCs were fewer, larger, and localized to neighboring microglia. We identified age-increased p16/Cdkn2a-expressing OPCs enriched for senescence-related pathways and distinct senescence signatures between hippocampus and fimbria. Aged brain OPC populations differ in microenvironment properties and responses to senescence-directed intervention.

少突胶质前体细胞（OPCs）的年龄相关变化会导致白质功能障碍。我们推测，在老年小鼠中，与海马体OPCs相比，富含髓磷脂的海马伞OPCs具有特定微环境的特性。老年海马伞OPCs数量减少、细胞体积增大，并定位于邻近的小胶质细胞。我们发现，表达p16/Cdkn2a的OPCs随着年龄增长而增多，这些细胞富集了衰老相关通路，且海马体和海马伞之间存在明显的衰老特征。老年大脑中的OPC群体在微环境特性以及对衰老定向干预的反应方面存在差异。